Discordant twins as a tool to unravel the aetiology of bipolar disorder.

C Fagnani, M Bellani, J C Soares, M A Stazi, P Brambilla

Abstract read

In one paragraph

Article in Epidemiology and psychiatric sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it

0cells of the map it votes in

5citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

Quantitative sensory testing and chronic pain syndromes: a cross-sectional study from TwinsUK.BMJ open · 2024
Article
The inferior frontal gyrus and familial risk for bipolar disorder.Psychoradiology · 2022
Review
Twin studies for the investigation of the relationships between genetic factors and brain abnormalities in bipolar disorder.Epidemiology and psychiatric sciences · 2016
Article
The relationship between anxiety disorders and dimensional representations of DSM-IV personality disorders: A co-twin control study.Journal of affective disorders · 2016
Article
Disruption of sonic hedgehog signaling in Ellis-van Creveld dwarfism confers protection against bipolar affective disorder.Molecular psychiatry · 2015
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

C FagnaniGenetic Epidemiology Unit, National Centre of Epidemiology, Surveillance and Health Promotion, Italian National Institute of Health, Rome, Italy.

M BellaniDepartment of Public Health and Community Medicine, Section of Psychiatry and Clinical Psychology, Inter-University Centre for Behavioural Neurosciences (ICBN), University of Verona, Verona, Italy.

J C SoaresDepartment of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, USA.

M A StaziGenetic Epidemiology Unit, National Centre of Epidemiology, Surveillance and Health Promotion, Italian National Institute of Health, Rome, Italy.

P BrambillaDepartment of Psychiatry and Behavioral Sciences, UT Houston Medical School, Houston, TX, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This editorial focuses on discordant twins as a valuable epidemiological design for psychiatric aetiological research. First, we summarise the advantages and strengths of this design over the classical matched case-control study. Then, we draw attention to the use of this method in bipolar disorder, revising previous discordant-twin studies. A future greater use of discordant twins is desirable to gain further relevant insights in the aetiology of bipolar disorder.

Identifiers

PMID24513394

DOI10.1017/S2045796014000055

PMCPMC6998188

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.