ArticleBiochimica et biophysica acta2014
Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species.
Article in Biochimica et biophysica acta, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 22 citations in OpenAlex.
- Optical Activation of Photoswitchable TRPC Ligands in the Mammalian Olfactory System Using Laser Scanning Confocal Microscopy.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Molecular feature of neutrophils in immune microenvironment of muscle atrophy.Journal of cellular and molecular medicine · 2022Review
- Photobiomodulation of avian embryos by red laser.Lasers in medical science · 2021Article
- Excitation light-induced phototoxicity during fluorescence imaging.Journal of biosciences · 2021Review
- Article
- Oxygen-sensitive interneurons exhibit increased activity and GABA release during ROS scavenging in the cerebral cortex of the western painted turtle.Journal of neurophysiology · 2019Article
- WITHDRAWN: Effect of He-Ne laser irradiation on embryonic development in chicken eggs.Progress in biophysics and molecular biology · 2019Article
- Non-photonic sensing of membrane-delimited reactive species with a NaScientific reports · 2017Article
- Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons.Pflugers Archiv : European journal of physiology · 2016Article
- Heterologous expression of NaV1.9 chimeras in various cell systems.Pflugers Archiv : European journal of physiology · 2015Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Reactive oxygen species (ROS) and reactive oxygen intermediates (ROI) play crucial roles in physiological processes. While excessive ROS damages cells, small fluctuations in ROS levels represent physiological signals important for vital functions. Despite the physiological importance of ROS, many fundamental questions remain unanswered, such as which types of ROS occur in cells, how they distribute inside cells, and how long they remain in an active form. The current study presents a ratiometric sensor of intracellular ROS levels based on genetically engineered voltage-gated sodium channels (roNaV). roNaV can be used for detecting oxidative modification that occurs near the plasma membrane with a sensitivity similar to existing fluorescence-based ROS sensors. Moreover, roNaV has several advantages over traditional sensors because it does not need excitation light for sensing, and thus, can be used to detect phototoxic cellular modifications. In addition, the ROS dynamic range of roNaV is easily manipulated in real time by means of the endogenous channel inactivation mechanism. Measurements on ROS liberated from intracellular Lucifer Yellow and genetically encoded KillerRed have revealed an assessment of ROS lifetime in individual mammalian cells. Flashlight-induced ROS concentration decayed with two major time constants of about 10 and 1000 ms.
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Registered trials
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