ArticleDrug and alcohol dependence2014
Substance abuse risk in emerging adults associated with smaller frontal gray matter volumes and higher externalizing behaviors.
Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Linking five-factor personality model to alcohol consumption in adolescence: a systematic review and meta-analysis.Alcohol and alcoholism (Oxford, Oxfordshire) · 2026Pooled it
- Prefrontal-Limbic Circuitry Is Associated With Reward Sensitivity in Nonhuman Primates.Biological psychiatry · 2024Article
- Sleep duration and brain MRI measures: Results from the SOL-INCA MRI study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Brain Changes Linked to Cognitive Symptomatology in Homeless Youth.Clinical nursing research · 2023Article
- How Age and E-cigarette Use Status Interact to Influence E-cigarette Ad Perceptions.Substance use & misuse · 2023Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- Differences in cortical morphology and child internalizing or externalizing problems: Accounting for the co-occurrence.JCPP advances · 2022Article
- Relationships between Personality Traits and Brain Gray Matter Are Different in Risky and Non-risky Drivers.Behavioural neurology · 2022Article
- Alcohol use in emerging adults associated with lower rich-club connectivity and greater connectome network disorganization.Drug and alcohol dependence · 2022Article
- Alcohol and the Brain.Nutrients · 2021Review
- Subtypes of inhibitory and reward activation associated with substance use variation in adolescence: A latent profile analysis of brain imaging data.Cognitive, affective & behavioral neuroscience · 2021Article
- Alcohol use in young adults associated with cortical gyrification.Drug and alcohol dependence · 2020Article
- Cigarette smoking and gray matter brain volumes in middle age adults: the CARDIA Brain MRI sub-study.Translational psychiatry · 2019Article
- Research Review: What have we learned about adolescent substance use?Journal of child psychology and psychiatry, and allied disciplines · 2018Review
- Reduced Orbitofrontal Gray Matter Concentration as a Marker of Premorbid Childhood Trauma in Cocaine Use Disorder.Frontiers in human neuroscience · 2018Article
- Neurobiology of substance use in adolescents and potential therapeutic effects of exercise for prevention and treatment of substance use disorders.Birth defects research · 2017Review
- TLR4 Methylation Moderates the Relationship Between Alcohol Use Severity and Gray Matter Loss.Journal of studies on alcohol and drugs · 2017Article
- Adolescence and Drug Use Vulnerability: Findings from Neuroimaging.Current opinion in behavioral sciences · 2017Article
- Negative and interactive effects of sex, aging, and alcohol abuse on gray matter morphometry.Human brain mapping · 2016Article
- Selective Mapping of Psychopathy and Externalizing to Dissociable Circuits for Inhibitory Self-Control.Clinical psychological science : a journal of the Association for Psychological Science · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
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Abstract
backgroundDuring emerging adulthood, alcohol and substance use peak. Previous research has suggested that prefrontal and subcortical brain volumes may relate to risk for development of substance abuse. Epidemiological studies indicate that early initiation of alcohol or drug use significantly increases the likelihood of later substance use disorder diagnoses. We hypothesized that frontal regions would be smaller in young adults with early substance use and related problems (early-risk, ER), compared with a control group without early use/problems (C). We further hypothesized that these volumes would be associated with more externalizing behaviors, an additional robust predictor of substance abuse.
methodsOne hundred and six subjects, ages 18-23, underwent high-resolution anatomical magnetic resonance image scanning. Individuals were categorized as C (n=64) or ER (n=42) using a composite-score of early alcohol/drug use and problems based on prospectively collected assessments; externalizing behaviors were also previously assessed during adolescence. Neuroanatomical volumes were compared between groups and correlated with behavioral measures.
resultsER subjects exhibited more externalizing behaviors than their control counterparts. Total left frontal cortex and left superior frontal cortex volumes were significantly smaller in the ER group, controlling for family history of alcoholism and current substance use. Total gray matter volumes were negatively associated with substance risk score. Further, externalizing behavior score was negatively correlated with both left superior cortical and left total cortical volumes.
conclusionsThese findings suggest that smaller frontal cortical volumes, specifically the left superior frontal cortex, represent an underlying risk factor for substance abuse in emerging adults.
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