ReviewSteroids2014
5β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1).
Review in Steroids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 53 citations in OpenAlex.
- Targeted lipidomics unveils complex lipids in cervicovaginal environment as diagnostic and prognostic biomarkers for endometrial cancer.BMC medicine · 2026Article
- Liver X Receptor α (LXRα) Regulates 5β-Reductase (AKR1D1) Expression in Avian Embryos: Implications for Yolk Steroid Metabolism.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2026Article
- Article
- Expansion of the Stereochemical Space of Triterpenes by Mining Noncanonical Oxidosqualene Cyclases Across the Diversity of Green Plants.Journal of the American Chemical Society · 2025Article
- Transcriptome Analysis Reveals Differential Gene Regulation in Ovarian Tissues of Anabas testudineus (Bloch, 1792) in Response to Insecticide, Monocrotophos.Marine biotechnology (New York, N.Y.) · 2025Article
- Dynamic change of estrogen and progesterone metabolites in human urine during pregnancy.Scientific reports · 2025Article
- In Vitro Analysis of AKR1D1 Interactions with Clopidogrel: Effects on Enzyme Activity and Gene Expression.Balkan journal of medical genetics : BJMG · 2024Article
- 5β-Dihydrosteroids: Formation and Properties.International journal of molecular sciences · 2024Review
- AKR1D1 knockout mice develop a sex-dependent metabolic phenotype.The Journal of endocrinology · 2022Article
- Article
- Glucocorticoids regulate AKR1D1 activity in human liver in vitro and in vivo.The Journal of endocrinology · 2020Article
- Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.The Journal of steroid biochemistry and molecular biology · 2019Review
- AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease.Metabolism: clinical and experimental · 2019Article
- Steroids in Stroke with Special Reference to Progesterone.Cellular and molecular neurobiology · 2019Review
- AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells.The Journal of steroid biochemistry and molecular biology · 2019Article
- ThePharmacogenomics and personalized medicine · 2019Article
- Dysregulation of ΔMolecular and cellular endocrinology · 2018Article
- Intracrine androgen biosynthesis, metabolism and action revisited.Molecular and cellular endocrinology · 2018Review
- A Role of Endogenous Progesterone in Stroke Cerebroprotection Revealed by the Neural-Specific Deletion of Its Intracellular Receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Planar bile acids in health and disease.Biochimica et biophysica acta. Biomembranes · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
5β-Reduced steroids are non-planar steroids that have a 90° bend in their structure to create an A/B cis-ring junction. This novel property is required for bile-acids to act as emulsifiers, but in addition 5β-reduced steroids have remarkable physiology and may act as potent tocolytic agents, endogenous cardiac glycosides, neurosteroids, and can act as ligands for orphan and membrane bound receptors. In humans there is only a single 5β-reductase gene AKR1D1, which encodes Δ(4)-3-ketosteroid-5β-reductase (AKR1D1). This enzyme is a member of the aldo-keto reductase superfamily, but possesses an altered catalytic tetrad, in which Glu120 replaces the conserved His residue. This predominant liver enzyme generates all 5β-dihydrosteroids in the C19-C27 steroid series. Mutations exist in the AKR1D1 gene, which result in loss of protein stability and are causative in bile-acid deficiency.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.