Evidence map›Paper›PMID 24513051›Full record

ArticleSteroids2014

26-Desmethyl-2-methylene-22-ene-19-nor-1α,25-dihydroxyvitamin D3 compounds selectively active on intestine.

Grazia Chiellini, Pawel Grzywacz, Lori A Plum, Margaret Clagett-Dame, Hector F DeLuca

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Steroids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 87% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Grazia ChielliniDepartment of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Pawel GrzywaczDepartment of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Lori A PlumDepartment of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Margaret Clagett-DameDepartment of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA.
Hector F DeLucaDepartment of Biochemistry, College of Agriculture and Life Sciences, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA. Electronic address: deluca@biochem.wisc.edu.
University of Wisconsin–Madison · US

Funding

WATER DISTRIB:PHYSICAL PROPERT:PIZZA &LMPS MOZZARELLA CHEESES:EARLY STAGE MATURP41RR002301 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI KEUTSCH, FRANK · 1985 to 2011
$13.0M
900 MHz NMR Spectrometer Biomolecular InvestigationsP41GM066326 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN L · 2002 to 2006
$5.0M
WIDE-BORE 9.4 TESLA NMR SPECTROMETER FOR UW-MADISONS10RR002781 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 1986 to 1986
–
CONSOLE UPGRADES FOR NMR FACILITYS10RR008438 · NCRR · UNIVERSITY OF WISCONSIN MADISON · PI MARKLEY, JOHN L · 1993 to 1993
–
NCRR NIH HHS P41 RR002301NCRR NIH HHS P41RR02301NCRR NIH HHS S10 RR002781NCRR NIH HHS S10 RR008438NIGMS NIH HHS P41 GM066326NIGMS NIH HHS P41GM66326
6 · The paper itself

Abstract

Six new analogs of 2-methylene-19-nor-1α,25-dihydroxyvitamin D3, 6-7 and 8a,b-9a,b, have been synthesized. All compounds are characterized by a trans double bond located in the side chain between C-22 and C-23. While compounds 6 and 7 possess C-26 and C-27 methyls, compounds 8a,b and 9a,b lack one of these groups. A Lythgoe-based synthesis, employing the Wittig-Horner reaction was used for these preparations. Two different types of Δ(22)E-25-hydroxy Grundmann's ketone, having either only one stereogenic center located at position C-20 (20 and 21), or two stereogenic centers located at 20- and 25-positions (24a,b-25a,b) were obtained by a multi-step procedure from commercial vitamin D2. The introduction of a double bond at C-22 appeared to lower biological activity in vitro and in vivo. Further removal of a 26-methyl in these analogs had little effect on receptor binding, HL-60 differentiation and CYP24A expression but markedly diminished or eliminated in vivo activity on bone calcium mobilization while retaining activity on intestinal calcium transport.

Indexed as

AnimalsBiological TransportBone and BonesCalcitriolCalciumCell DifferentiationHL-60 CellsHumansIntestinal MucosaIntestinesOrgan SpecificityRatsReceptors, CalcitriolVitamin DCalcitriolCalciumdihydroxy-vitamin D3Receptors, CalcitriolVitamin DCalcemic activityTranscription activityVitamin D

Identifiers

PMID24513051
PMCPMC4601567
OpenAlexW2080702256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.