Evidence map›Paper›PMID 24513050›Full record

ArticleBioorganic & medicinal chemistry letters2014

Targeted amplification of delivery to cell surface receptors by dendrimer self-assembly.

Steven Isaacman, Michael Buckley, Xiaojian Wang, Edwin Y Wang, Leonard Liebes, James W Canary

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Steven IsaacmanDepartment of Chemistry, New York University, New York, NY 10003, USA; Nanometics LLC, 111 Great Neck Rd, Suite 212, Great Neck, NY 11021, USA.
Michael BuckleyCancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Xiaojian WangDepartment of Chemistry, New York University, New York, NY 10003, USA.
Edwin Y WangDepartment of Radiology, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
Leonard LiebesCancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA.
James W CanaryDepartment of Chemistry, New York University, New York, NY 10003, USA; Cancer Institute, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA. Electronic address: canary@nyu.edu.
New York University · USNanometics (United States) · US

Funding

Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1M
NCI NIH HHS P30 CA016087
6 · The paper itself

Abstract

Nanometer-scale architectures assembled on cell surface receptors from smaller macromolecular constituents generated a large amplification of fluorescence. A targeted dendrimer was synthesized from a cystamine-core G4 PAMAM dendrimer, and contained an anti-BrE3 monoclonal antibody as the targeting group, several fluorophores and an average of 12 aldehyde moieties as complementary bio-orthogonal reactive sites for the covalent assembly. A cargo dendrimer, derived from a PAMAM G4 dendrimer, contained several fluorophores as the cargo for delivery and five hydrazine moieties as complimentary bio-orthogonal reactive sites. The system is designed to be flexible and allow for facile incorporation of a variety of targeting ligands.

Indexed as

Antibodies, MonoclonalCell Line, TumorDendrimersDrug CarriersFluorescent DyesHumansNylonsReceptors, Cell SurfaceRhodaminesAntibodies, MonoclonalDendrimersDrug CarriersFluorescent DyesNylonsPAMAM-G4Receptors, Cell SurfaceRhodaminesCell surface self-assemblyDendrimerTargeted amplification

Identifiers

PMID24513050
PMCPMC5090713
OpenAlexW2045575691

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.