Evidence map›Paper›PMID 24512963›Full record

ArticleComparative medicine2014

Transmission of Chagas disease via blood transfusions in 2 immunosuppressed pigtailed macaques (Macaca nemestrina).

Derek L Fong, Annie E Torrence, Keith W Vogel, Diane E Stockinger, Veronica Nelson, Robert D Murnane, Audrey Baldessari, LaRene Kuller, Michael Agy, Hans-Peter Kiem and 1 more

Open access · greenAbstract readCase Reports
PubMed Full text at PMC
In one paragraph

Article in Comparative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Reproductive Outcomes in Rhesus Macaques (Comparative medicine · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Derek L FongWashington National Primate Research Center, University of Washington, Seattle, Washington, USA. Derek.Fong@ucdenver.edu.
Annie E TorrenceWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Keith W VogelWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Diane E StockingerWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Veronica NelsonClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Robert D MurnaneWashington National Primate Research Center, University of Washington, Seattle, Washington, USA; Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
Audrey BaldessariWashington National Primate Research Center, University of Washington, Seattle, Washington, USA; Department of Comparative Medicine, University of Washington, Seattle, Washington, USA.
LaRene KullerWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Michael AgyWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
Hans-Peter KiemClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Charlotte E HotchkissWashington National Primate Research Center, University of Washington, Seattle, Washington, USA.
University of Washington · USFred Hutch Cancer Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 2.25-y-old male pigtailed macaque (Macaca nemestrina) was experimentally irradiated and received a bone marrow transplant. After transplantation and engraftment, the macaque had unexpected recurring pancytopenia and dependent edema of the prepuce, scrotum, and legs. The diagnostic work-up included a blood smear, which revealed a trypomastigote consistent with Trypanosoma cruzi, the causative agent of Chagas disease (CD). We initially hypothesized that the macaque had acquired the infection when it lived in Georgia. However, because the animal had received multiple blood transfusions, all blood donors were screened for CD. One male pigtailed macaque blood donor, which was previously housed in Louisiana, was positive for T. cruzi antibodies via serology. Due to the low prevalence of infection in Georgia, the blood transfusion was hypothesized to be the source of T. cruzi infection. The transfusion was confirmed as the mechanism of transmission when screening of archived serum revealed seroconversion after blood transfusion from the seropositive blood donor. The macaque made a full clinical recovery, and further follow-up including thoracic radiography, echocardiography, and gross necropsy did not show any abnormalities associated with CD. Other animals that received blood transfusions from the positive blood donor were tested, and one additional pigtailed macaque on the same research protocol was positive for T. cruzi. Although CD has been reported to occur in many nonhuman primate species, especially pigtailed macaques, the transmission of CD via blood transfusion in nonhuman primates has not been reported previously.

Indexed as

Immunocompromised HostAnimalsAntibodies, ProtozoanBiomarkersBlood TransfusionChagas DiseaseDose Fractionation, RadiationGenetic TherapyMacaca nemestrinaMaleModels, AnimalMonkey DiseasesStem Cell TransplantationTransfusion ReactionTrypanosoma cruziAntibodies, ProtozoanBiomarkers

Identifiers

PMID24512963
PMCPMC3929221
OpenAlexW87664318

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.