ArticleComparative medicine2014
Effects of diet-induced obesity on metabolic parameters and reproductive function in female Ossabaw minipigs.
Article in Comparative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 44 citations in OpenAlex.
- Farm animal models for the study of the reproductive features of polyendocrine metabolic ovarian syndrome.Frontiers in endocrinology · 2026Review
- Case Report: A case study on the relationship between obesity and estrus in female captive panda.Frontiers in veterinary science · 2025Article
- Article
- Sheep with ovarian androgen excess have fibrosis and follicular arrest with increased mRNA abundance for steroidogenic enzymes and gonadotropin receptors.Journal of animal science · 2023Article
- High-Fat Diet and Female Fertility across Lifespan: A Comparative Lesson from Mammal Models.Nutrients · 2022Review
- Naturally occurring androgen excess cows are present in dairy and beef herds and have similar characteristics to women with PCOS.Journal of animal science · 2022Article
- Fructose metabolism and its role in pig production: A mini-review.Frontiers in nutrition · 2022Review
- Palatable high-fat diet intake influences mnemonic and emotional aspects in female rats in an estrous cycle-dependent manner.Metabolic brain disease · 2021Article
- Virilizing doses of testosterone decrease circulating insulin levels and differentially regulate insulin signaling in liver and adipose tissue of females.American journal of physiology. Endocrinology and metabolism · 2021Article
- Gut and Vagina Microbiota Associated With Estrus Return of Weaning Sows and Its Correlation With the Changes in Serum Metabolites.Frontiers in microbiology · 2021Article
- Dyslipidemia Is Negatively Associated With the Cumulative Live-Birth Rate in Patients Without PCOS Following IVF/ICSI.Frontiers in physiology · 2021Article
- Article
- Effect of high-fat diet on the various morphological parameters of the ovary.Anatomy & cell biology · 2020Article
- Dietary substitution of soybean oil with coconut oil in the absence of dietary antibiotics supports growth performance and immune function in nursery and grower pigs.Journal of animal science and biotechnology · 2020Article
- Livestock animals to study infertility in women.Animal frontiers : the review magazine of animal agriculture · 2019Article
- Syzygium cumini (L.) Skeels improves metabolic and ovarian parameters in female obese rats with malfunctioning hypothalamus-pituitary-gonadal axis.Journal of ovarian research · 2019Article
- Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging.BioMed research international · 2019Article
- Effect of metabolic syndrome and aging on CaExperimental gerontology · 2018Article
- The Ossabaw Pig Is a Suitable Translational Model to Evaluate Dietary Patterns and Coronary Artery Disease Risk.The Journal of nutrition · 2018Article
- Ossabaw Pigs With a PCSK9 Gain-of-Function Mutation Develop Accelerated Coronary Atherosclerotic Lesions: A Novel Model for Preclinical Studies.Journal of the American Heart Association · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
This study characterizes the effect of an excess-calorie, high-fat, high-cholesterol, high-fructose diet on metabolic parameters and reproductive function in female Ossabaw minipigs. Cycling sows were fed a hypercaloric, high-fat, high-cholesterol, and high-fructose diet (obese, n = 4) or a control diet (control, n = 5) for 13 mo. During the final 4 mo, ovarian ultrasonography was done, blood was collected, and weights and measures were taken. Pigs then underwent ovarian stimulation. Cycle length and androstenedione, total testosterone, progesterone, estradiol, follicle-stimulating hormone, luteinizing hormone, insulin, fructosamine, lipid, and glucose levels were measured. In addition, adipose tissue aromatase gene expression was assessed. As compared with control pigs, obese pigs were hyperglycemic and hyperinsulinemic; had elevated total cholesterol, triglyceride, and leptin levels, and demonstrated abdominal adiposity. Visceral adipose tissue of obese pigs, as compared with control pigs, showed increased aromatase gene expression. Obese pigs had longer estrous cycles, higher serum androstenedione, and higher luteal phase serum luteinizing hormone, compared with control pigs. During the luteal phase, obese pigs had more medium, ovulatory, and cystic ovarian follicles, whereas control pigs had more small ovarian follicles. When fed an excess-calorie, high-fat, high-cholesterol, high-fructose diet, female Ossabaw minipigs develop obesity, metabolic syndrome, and abnormal reproductive function. This animal model may be applicable to studies of the effects of obesity on fertility in women.
Indexed as
Identifiers
24512960PMC3929218W158376530What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.