ArticleComparative medicine2014
Effects of sleep fragmentation on sleep and markers of inflammation in mice.
Article in Comparative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 30 citations in OpenAlex.
- Acute sleep deprivation alters hypothalamic neuroinflammatory signaling independent of traumatic brain injury in the mouse.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Melatonin Mitigates Sleep Restriction-Induced Cognitive and Glymphatic Dysfunction Via Aquaporin-4 Polarization.Molecular neurobiology · 2025Article
- The cardiovascular consequences of chronic sleep fragmentation: Evidence from experimental models of obstructive sleep apnea.Sleep medicine · 2025Article
- Sleep and immune health: How dogs, goats and 'factor S' shaped a field.Neurobiology of sleep and circadian rhythms · 2025Article
- Article
- Selective REM sleep restriction in mice using a device designed for tunable somatosensory stimulation.Journal of neuroscience methods · 2024Article
- Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice.Frontiers in behavioral neuroscience · 2023Article
- Experimental Models to Study End-Organ Morbidity in Sleep Apnea: Lessons Learned and Future Directions.International journal of molecular sciences · 2022Review
- CPAP Intervention as an Add-On Treatment to Lipid-Lowering Medication in Coronary Artery Disease Patients with Obstructive Sleep Apnea in the RICCADSA Trial.Journal of clinical medicine · 2022Article
- Differential Effect of Light and Dark Period Sleep Fragmentation on Composition of Gut Microbiome and Inflammation in Mice.Life (Basel, Switzerland) · 2021Article
- The Associations Between Sleep Architecture and Metabolic Parameters in Patients With Obstructive Sleep Apnea: A Hospital-Based Cohort Study.Frontiers in neurology · 2021Article
- Anxiogenic Potential of Experimental Sleep Fragmentation Is Duration-Dependent and Mediated via Oxidative Stress State.Oxidative medicine and cellular longevity · 2021Article
- Early Transcriptomic Response to OxLDL in Human Retinal Pigment Epithelial Cells.International journal of molecular sciences · 2020Article
- Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption.CNS neuroscience & therapeutics · 2020Article
- Interacting Influences of Sleep, Pain, and Analgesic Medications on Sleep Studies in Rodents.Comparative medicine · 2019Review
- Relationships between cardiometabolic disorders and obstructive sleep apnea: Implications for cardiovascular disease risk.Journal of clinical hypertension (Greenwich, Conn.) · 2019Observational
- Effects of Chronic Diurnal Disruption and Acute Inflammatory Challenge on Mice with Latent Murine Gammaherpesvirus Infection.Comparative medicine · 2016Article
- Effects of sleep disruption and high fat intake on glucose metabolism in mice.Psychoneuroendocrinology · 2016Article
- Independent Association between Sleep Fragmentation and Dyslipidemia in Patients with Obstructive Sleep Apnea.Scientific reports · 2016Article
- Sleep Apnea Research in Animals. Past, Present, and Future.American journal of respiratory cell and molecular biology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Many people in our society experience curtailment and disruption of sleep due to work responsibilities, care-giving, or life style choice. Delineating the health effect of acute and chronic disruptions in sleep is essential to raising awareness of and creating interventions to manage these prevalent concerns. To provide a platform for studying the health impact and underlying pathophysiologic mechanisms associated with inadequate sleep, we developed and characterized an approach to creating chronic disruption of sleep in laboratory mice. We used this method to evaluate how 3 durations of sleep fragmentation (SF) affect sleep recuperation and blood and lung analyte concentrations in male C57BL/6J mice. Mice housed in environmentally controlled chambers were exposed to automated SF for periods of 6, 12, or 24 h or for 12 h daily during the light (somnolent) phase for 4 sequential days. Sleep time, slow-wave amplitude, or bout lengths were significantly higher when uninterrupted sleep was permitted after each of the 3 SF durations. However, mice did not recover all of the lost slow-wave sleep during the subsequent 12- to 24-h period and maintained a net loss of sleep. Light-phase SF was associated with significant changes in serum and lung levels of some inflammatory substances, but these changes were not consistent or sustained. The data indicate that acute light-phase SF can result in a sustained sleep debt in mice and may disrupt the inflammatory steady-state in serum and lung.
Indexed as
Identifiers
24512957PMC3929215W2346906636What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.