ArticleFree radical biology & medicine2014
The cellular distribution of extracellular superoxide dismutase in macrophages is altered by cellular activation but unaffected by the naturally occurring R213G substitution.
Article in Free radical biology & medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Extracellular Superoxide Dismutase in Acute Respiratory Distress Syndrome: Pathogenic Mechanisms and Therapeutic Implications.Antioxidants (Basel, Switzerland) · 2026Review
- Do oxidized low-density lipoproteins link to extra hepatic manifestations in chronic, non-cirrhotic HCV patients?Metabolism open · 2025Article
- Release of extracellular superoxide dismutase into alveolar fluid protects against acute lung injury and inflammation inAmerican journal of physiology. Lung cellular and molecular physiology · 2023Article
- Novel and Converging Ways of NOX2 and SOD3 in Trafficking and Redox Signaling in Macrophages.Antioxidants (Basel, Switzerland) · 2021Review
- Redistribution of EC-SOD resolves bleomycin-induced inflammationFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Characterization of extracellular redox enzyme concentrations in response to exercise in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- The dynamic uptake and release of SOD3 from intracellular stores in macrophages modulates the inflammatory response.Redox biology · 2019Article
- Mitochondria in innate immune signaling.Translational research : the journal of laboratory and clinical medicine · 2018Review
- R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways.Physiological genomics · 2018Article
- Review
- Extracellular superoxide dismutase and its role in cancer.Free radical biology & medicine · 2017Review
- Article
- Superoxide Dismutase 3 R213G Single-Nucleotide Polymorphism Blocks Murine Bleomycin-Induced Fibrosis and Promotes Resolution of Inflammation.American journal of respiratory cell and molecular biology · 2017Article
- Interleukin-27 Enhances the Potential of Reactive Oxygen Species Generation from Monocyte-derived Macrophages and Dendritic cells by Induction of p47Scientific reports · 2017Article
- Reactive oxygen species and mitochondria: A nexus of cellular homeostasis.Redox biology · 2015Review
- Overexpression of superoxide dismutase 3 gene blocks high-fat diet-induced obesity, fatty liver and insulin resistance.Gene therapy · 2014Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
Extracellular superoxide dismutase (EC-SOD) is responsible for the dismutation of the superoxide radical produced in the extracellular space and known to be expressed by inflammatory cells, including macrophages and neutrophils. Here we show that EC-SOD is produced by resting macrophages and associated with the cell surface via the extracellular matrix (ECM)-binding region. Upon cellular activation induced by lipopolysaccharide, EC-SOD is relocated and detected both in the cell culture medium and in lipid raft structures. Although the secreted material presented a significantly reduced ligand-binding capacity, this could not be correlated to proteolytic removal of the ECM-binding region, because the integrity of the material recovered from the medium was comparable to that of the cell surface-associated protein. The naturally occurring R213G amino acid substitution located in the ECM-binding region of EC-SOD is known to affect the binding characteristics of the protein. However, the analysis of macrophages expressing R213G EC-SOD did not present evidence of an altered cellular distribution. Our results suggest that EC-SOD plays a dynamic role in the inflammatory response mounted by activated macrophages.
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Registered trials
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