ArticleWorld journal of emergency surgery : WJES2014
Position paper: timely interventions in severe acute pancreatitis are crucial for survival.
Article in World journal of emergency surgery : WJES, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Management of Acute Pancreatitis in the Pediatric Population: A Clinical Report From the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Pancreas Committee.Journal of pediatric gastroenterology and nutrition · 2018Guideline
- Global, regional and national burden of pancreatitis in children and adolescents, 1990-2021: a systematic analysis for the global burden of disease study 2021.Annals of medicine · 2025Article
- Acute Necrotizing Pancreatitis-Advances and Challenges in Management for Optimal Clinical Outcomes.Medicina (Kaunas, Lithuania) · 2025Review
- Abdominal Compartment Syndrome in Acute Pancreatitis: A Narrative Review.Diagnostics (Basel, Switzerland) · 2022Review
- Effect of Different-Volume Fluid Resuscitation on Organ Functions in Severe Acute Pancreatitis and Therapeutic Effect ofEvidence-based complementary and alternative medicine : eCAM · 2020Article
- Targeting neutrophil extracellular traps in severe acute pancreatitis treatment.Therapeutic advances in gastroenterology · 2020Review
- 2019 WSES guidelines for the management of severe acute pancreatitis.World journal of emergency surgery : WJES · 2019Review
- Recognition and management of intra-abdominal hypertension and abdominal compartment syndrome; a survey among Dutch surgeons.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2017Article
- Targeting MicroRNA Function in Acute Pancreatitis.Frontiers in physiology · 2017Review
- Intra-abdominal pressure: Time ripe to revise management guidelines of acute pancreatitis?World journal of gastrointestinal pathophysiology · 2016Article
- Angiopoietin-2 Is an Early Indicator of Acute Pancreatic-Renal Syndrome in Patients with Acute Pancreatitis.Mediators of inflammation · 2016Article
- AcanthopanaxMediators of inflammation · 2016Article
- Fluid resuscitation in acute pancreatitis.World journal of gastroenterology · 2014Review
- Increased of serum high-mobility group box chromosomal protein 1 correlated with intestinal mucosal barrier injury in patients with severe acute pancreatitis.World journal of emergency surgery : WJES · 2014Article
- D-dimer as a Marker of Severity and Prognosis in Acute Pancreatitis.International journal of applied & basic medical researchArticle
- Acute necrotizing pancreatitis: can tigecycline be included in a therapeutic strategy?Il Giornale di chirurgiaArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Severe acute pancreatitis has high mortality, but multiple and timely interventions can improve survival. Early in the course of the disease aggressive fluid resuscitation is needed for the prevention and treatment of shock. In conjunction with leaking capillaries this results in increased tissue edema, which may lead to intra-abdominal hypertension and abdominal compartment syndrome. Invasive hemodynamic monitoring is essential for optimizing fluid therapy while monitoring of intra-abdominal pressure is necessary for identification patients at risk of developing abdominal compartment syndrome. Abdominal compartment syndrome develops usually within the first days after hospitalization. Conservative treatment modalities are useful in prevention but also in the treatment of abdominal compartment syndrome. If conservative management fails surgical decompression of abdomen may be needed. Multiple organ dysfunction syndrome and increased intra-abdominal pressure predispose patients with severe pancreatitis to secondary infections. Extrapancreatic infections predominate during the first week of the disease, whereas infection of pancreatic necrosis usually develops later. Early enteral nutrition reduces the risk of infections whereas advantage of prophylactic antibiotics is lacking evidence. Surgery for infected pancreatic necrosis is associated with high mortality when performed within the first two weeks of the disease. Therefore surgery should be postponed as late as possible, preferably later than four weeks after disease onset.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.