Evidence map›Paper›PMID 24512640›Full record

ReviewCNS spectrums2014

New developments in human neurocognition: clinical, genetic, and brain imaging correlates of impulsivity and compulsivity.

Naomi A Fineberg, Samuel R Chamberlain, Anna E Goudriaan, Dan J Stein, Louk J M J Vanderschuren, Claire M Gillan, Sameer Shekar, Philip A P M Gorwood, Valerie Voon, Sharon Morein-Zamir and 5 more

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in CNS spectrums, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04631042 (An Observational Study of the Developing Brain, Impulsivity and Compulsivity), which is not on this map. Cited by 195 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
195citing papers in PubMed, 14 pooled it
38.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04631042 recruitingnot on this mapstarted 2022, after this paper: background citation

An Observational Study of the Developing Brain, Impulsivity and Compulsivity

TypeobservationalSponsorNational Institute of Mental Health (NIMH)Ran2022 to 2031Enrolled1,100ConditionsTypical Development, Obsessive Compulsive Disorder, Conduct Disorder, Attention Deficit Hyperactivity Disorder
3 · Its place in the literature

Who cites it

195 citing papers in PubMed, 14 syntheses or guidelines pooled it, 486 citations in OpenAlex.

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  7. Impulsivity and compulsivity in binge eating disorder: A systematic review of behavioral studies.Progress in neuro-psychopharmacology & biological psychiatry · 2021
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  15. Relationships between generalized impulsivity and subjective stimulant and sedative responses following alcohol administration.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2019
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135 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 5 countries.

Naomi A Fineberg1 Hertfordshire Partnership NHS University Foundation Trust, Queen Elizabeth II Hospital, Howlands, Welwyn Garden City, Hertfordshire, UK.
Samuel R Chamberlain3 School of Clinical Medicine, Cambridge University, Addenbrooke's Hospital, Cambridge, UK.
Anna E Goudriaan5 Department of Psychiatry, Amsterdam Institute for Addiction Research, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
Dan J Stein7 Department of Psychiatry, University of Cape Town, Cape Town, South Africa.
Louk J M J Vanderschuren8 Department of Animals in Science and Society, Division of Behavioural Neuroscience, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
Claire M Gillan10 Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK.
Sameer Shekar1 Hertfordshire Partnership NHS University Foundation Trust, Queen Elizabeth II Hospital, Howlands, Welwyn Garden City, Hertfordshire, UK.
Philip A P M Gorwood12 INSERM UMR894 (Centre of Psychiatry and Neuroscience), Paris, France.
Valerie Voon10 Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK.
Sharon Morein-Zamir10 Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK.
Damiaan Denys15 Department of Psychiatry, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Barbara J Sahakian3 School of Clinical Medicine, Cambridge University, Addenbrooke's Hospital, Cambridge, UK.
F Gerard Moeller17 Departments of Psychiatry and Pharmacology and Toxicology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Trevor W Robbins10 Behavioural and Clinical Neuroscience Institute (BCNI), University of Cambridge, Cambridge, UK.
Marc N Potenza18 Departments of Psychiatry, Child Study and Neurobiology, Yale School of Medicine, New Haven, Connecticut, USA.
University of Cambridge · GBCambridgeshire and Peterborough NHS Foundation Trust · GBInserm · FRNetherlands Institute for Neuroscience · NLQueen Elizabeth II Hospital · GBUniversity of Amsterdam · NLUniversity of Cape Town · ZAUniversity of Hertfordshire · GBUtrecht University · NLVirginia Commonwealth University · USYale University · US

Funding

Translational MR Imaging in Cocaine Pharmacotherapy DevelopmentP50DA009262 · NIDA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MOELLER, FREDERICK GERARD · 1994 to 2014
$26.9M
Center for Clinical and Translational ResearchUL1TR000058 · NCATS · VIRGINIA COMMONWEALTH UNIVERSITY · PI MOELLER, FREDERICK GERARD · 2012 to 2015
$12.5M
Translational Addiction Sciences CenterP50DA033935 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2013 to 2017
$6.7M
Behavioral Technologies for Predicting HIV RiskR01DA018647 · NIDA · UNIV OF MARYLAND, COLLEGE PARK · PI FELTON, JULIA W · 2005 to 2014
$5.2M
Translational Center on Serotonin and Stimulant AddictionP20DA024157 · NIDA · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CUNNINGHAM, KATHRYN A. · 2007 to 2012
$4.2M
Translational Research of Cocaine, Striatum, and ImpulsivitiesP20DA027844 · NIDA · YALE UNIVERSITY · PI TAYLOR, JANE R · 2010 to 2013
$3.6M
Neural mechanisms of CBT in cocaine dependence (Gender Differences Supplement)R01DA035058 · NIDA · YALE UNIVERSITY · PI CARROLL, KATHLEEN M., POTENZA, MARC N · 2013 to 2016
$2.3M
fMRI of Craving in Addictions: Gender DifferencesR01DA019039 · NIDA · YALE UNIVERSITY · PI POTENZA, MARC N · 2005 to 2009
$1.6M
fMRI of Stress & Self-Control in Smoking & Obesity (7 of 14)RL1AA017539 · NIAAA · YALE UNIVERSITY · PI POTENZA, MARC N · 2007 to 2011
$1.3M
Social play behavior in periadolescent rats in relation to later drug abuseR01DA022628 · NIDA · UNIVERSITY MEDICAL CENTER UTRECHT · PI VANDERSCHUREN, LOUK JMJ · 2007 to 2011
$921k
Medical Research Council 093875/Z/10/ZMedical Research Council G0001354NCATS NIH HHS UL1 TR000058NIAAA NIH HHS RL1 AA017539NIDA NIH HHS DA022628NIDA NIH HHS P20 DA024157NIDA NIH HHS P20DA024157NIDA NIH HHS P20 DA027844NIDA NIH HHS P50 DA009262NIDA NIH HHS P50DA009262NIDA NIH HHS P50 DA033935NIDA NIH HHS R01 DA018647NIDA NIH HHS R01 DA 019039NIDA NIH HHS R01 DA019039NIDA NIH HHS R01 DA022628NIDA NIH HHS R01 DA035058Wellcome TrustWellcome Trust 89589/Z/09/Z
6 · The paper itself

Abstract

Impulsivity and compulsivity represent useful conceptualizations that involve dissociable cognitive functions, which are mediated by neuroanatomically and neurochemically distinct components of cortico-subcortical circuitry. The constructs were historically viewed as diametrically opposed, with impulsivity being associated with risk-seeking and compulsivity with harm-avoidance. However, they are increasingly recognized to be linked by shared neuropsychological mechanisms involving dysfunctional inhibition of thoughts and behaviors. In this article, we selectively review new developments in the investigation of the neurocognition of impulsivity and compulsivity in humans, in order to advance our understanding of the pathophysiology of impulsive, compulsive, and addictive disorders and indicate new directions for research.

Indexed as

AnimalsBehavior, AddictiveCognitive ScienceCompulsive BehaviorHumansImpulsive BehaviorPrognosisSubstance-Related Disorders

Identifiers

PMID24512640
PMCPMC4113335
OpenAlexW2087042918

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.