ArticleBMC complementary and alternative medicine2014
Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell (Scrophulariaceae).
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Bioactive metabolites from endophytic Fusarium equiseti isolated from Hyoscyamus muticus mitigate cadmium toxicity in biological models.Scientific reports · 2026Article
- Amesia nigricolor, a novel endophyte of Encephalartos bubalinus, exhibiting a robust taxol biosynthetic stability: chemical characterization and biological activities.Microbial cell factories · 2025Article
- GC-MS profiling, in vitro and in silico antibacterial and antioxidant potential of crude secondary metabolites of an endophytic bacterium isolated from Enhydra fluctuans lour.Scientific reports · 2025Article
- In Vitro Antioxidant and Antibacterial Activities of Ethyl Acetate Extracts ofMicroorganisms · 2024Article
- Article
- In Vitro Efficacy of Extracts and Isolated Bioactive Compounds from Ascomycota Fungi in the Treatment of Colorectal Cancer: A Systematic Review.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Evaluation of the anticarcinogenic potential of the endophyte, Streptomyces sp. LRE541 isolated from Lilium davidii var. unicolor (Hoog) Cotton.Microbial cell factories · 2021Article
- Bioprospecting of endophytic microorganisms for bioactive compounds of therapeutic importance.Archives of microbiology · 2021Review
- Bioprospecting of endophytes in medicinal plants of Thar Desert: An attractive resource for biopharmaceuticals.Biotechnology reports (Amsterdam, Netherlands) · 2021Review
- Isolation of endophytic bacteria from the leaves of Anredera cordifolia CIX1 for metabolites and their biological activities.BMC complementary medicine and therapies · 2020Article
- Diversity and bioactivities of fungal endophytes from Distylium chinense, a rare waterlogging tolerant plant endemic to the Three Gorges Reservoir.BMC microbiology · 2019Article
- Antimicrobial Activity of Terpenoids Extracted fromOpen access Macedonian journal of medical sciences · 2019Article
- Trichoderma lixii (IIIM-B4), an endophyte of Bacopa monnieri L. producing peptaibols.BMC microbiology · 2019Article
- Diversity of cultivable fungal endophytes in Paullinia cupana (Mart.) Ducke and bioactivity of their secondary metabolites.PloS one · 2018Article
- Molecular profiling and bioactive potential of an endophytic fungus Aspergillus sulphureus isolated from Sida acuta: a medicinal plant.Pharmaceutical biology · 2017Article
- Endophytic fungi associated with Monarda citriodora, an aromatic and medicinal plant and their biocontrol potential.Pharmaceutical biology · 2017Article
- Fungal endophytes associated with Viola odorata Linn. as bioresource for pancreatic lipase inhibitors.BMC complementary and alternative medicine · 2017Article
- Health Risks Associated with Exposure to Filamentous Fungi.International journal of environmental research and public health · 2017Review
- Article
- The Molecular Links of Re-Emerging Therapy: A Review of Evidence of Brahmi (Bacopa monniera).Frontiers in pharmacology · 2016Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEndophytes, which reside in plant tissues, have the potential to produce novel metabolites with immense benefits for health industry. Cytotoxic and antimicrobial activities of endophytic fungi isolated from Bacopa monnieri (L.) Pennell were investigated.
methodsEndophytic fungi were isolated from the Bacopa monnieri. Extracts from liquid cultures were tested for cytotoxicity against a number of cancer cell lines using the MTT assay. Antimicrobial activity was determined using the micro dilution method.
results22% of the examined extracts showed potent (IC50 of <20 μg/ml) cytotoxic activity against HCT-116 cell line. 5.5%, 11%, 11% of the extracts were found to be cytotoxic for MCF-7, PC-3, and A-549 cell lines respectively. 33% extracts displayed antimicrobial activity against at least one test organism with MIC value 10-100 μg/ml. The isolate B9_Pink showed the most potent cytotoxic activity for all the cell lines examined and maximum antimicrobial activity against the four pathogens examined which was followed by B19.
conclusionsResults indicated the potential for production of bioactive agents from endophytes of Bacopa monnieri.
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