ReviewAmerican journal of respiratory and critical care medicine2014
How outcomes are defined in clinical trials of mechanically ventilated adults and children.
Review in American journal of respiratory and critical care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Heterogeneity of surrogate outcome measures used in critical care studies: A systematic review.Clinical trials (London, England) · 2023Pooled it
- Measuring and Analyzing Length of Stay in Critical Care Trials.Medical care · 2019Pooled it
- Conservative fluid management or deresuscitation for patients with sepsis or acute respiratory distress syndrome following the resuscitation phase of critical illness: a systematic review and meta-analysis.Intensive care medicine · 2017Pooled it
- Diaries for recovery from critical illness.The Cochrane database of systematic reviews · 2014Pooled it
- Protocolized versus non-protocolized weaning for reducing the duration of mechanical ventilation in critically ill adult patients.The Cochrane database of systematic reviews · 2014Pooled it
- Article
- Re-analysis of ventilator-free days (VFD) in acute respiratory distress syndrome (ARDS) studies.Trials · 2023Article
- Evaluation of outcome reporting in clinical trials of physiotherapy in bronchiectasis: The first stage of core outcome set development.PloS one · 2023Article
- Cut-Off Values of the Post-Intensive Care Syndrome Questionnaire for the Screening of Unplanned Hospital Readmission within One Year.Journal of Korean Academy of Nursing · 2020Article
- Contemporary strategies to improve clinical trial design for critical care research: insights from the First Critical Care Clinical Trialists Workshop.Intensive care medicine · 2020Article
- A Core Outcome Set for Critical Care Ventilation Trials.Critical care medicine · 2019Article
- Duration of Postoperative Mechanical Ventilation as a Quality Metric for Pediatric Cardiac Surgical Programs.The Annals of thoracic surgery · 2018Article
- Supplemental Oxygen-Free Days in Hematopoietic Cell Transplant Recipients With Respiratory Syncytial Virus.The Journal of infectious diseases · 2017Article
- A critical view on primary and secondary outcome measures in nutrition trials.Intensive care medicine · 2017Article
- Article
- Comparison of Clinical Trial and Systematic Review Outcomes for the 4 Most Prevalent Eye Diseases.JAMA ophthalmology · 2017Article
- Article
- Is critical care ready for an economic surrogate endpoint?Critical care (London, England) · 2015Article
- Mortality is the only relevant outcome in ARDS: no.Intensive care medicine · 2015Article
- Mortality is the only relevant outcome in ARDS: yes.Intensive care medicine · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Systematic reviews have considerable potential to provide evidence-based data to aid clinical decision-making. However, there is growing recognition that trials involving mechanical ventilation lack consistency in the definition and measurement of ventilation outcomes, creating difficulties in combining data for meta-analyses. To address the inconsistency in outcome definitions, international standards for trial registration and clinical trial protocols published recommendations, effectively setting the "gold standard" for reporting trial outcomes. In this Critical Care Perspective, we review the problems resulting from inconsistent outcome definitions and inconsistent reporting of outcomes (outcome sets). We present data highlighting the variability of the most commonly reported ventilation outcome definitions. Ventilation outcomes reported in trials over the last 6 years typically fall into four domains: measures of ventilator dependence; adverse outcomes; mortality; and resource use. We highlight the need, first, for agreement on outcome definitions and, second, for a minimum core outcome set for trials involving mechanical ventilation. A minimum core outcome set would not restrict trialists from measuring additional outcomes, but would overcome problems of variability in outcome selection, measurement, and reporting, thereby enhancing comparisons across trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.