ArticleTexas Heart Institute journal2014
Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium.
Article in Texas Heart Institute journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Potential Cardiovascular Risks of Phenethylamine Analogues in Food Supplements: Evidence from Vasocontraction of Rat Artery Segments.Cardiovascular toxicology · 2026Article
- Quantitative in vitro-to-in vivo extrapolation of human adrenergic and trace amine-associated receptor 1 potencies of pre-workout supplement ingredients using physiologically based kinetic modelling-based reverse dosimetry.Archives of toxicology · 2025Article
- Cerebral Venous Sinus Thrombosis Linked to Dietary Supplement Use in a Bodybuilder: A Case Report.Clinical case reports · 2025Article
- Article
- Acute myocardial infarction following "dry scooping" of a pre-workout supplement in a healthy young man of African origin: A case report.SAGE open medical case reports · 2024Article
- The Alkylamine Stimulant 1,3-Dimethylamylamine Exhibits Substrate-Like Regulation of Dopamine Transporter Function and Localization.The Journal of pharmacology and experimental therapeutics · 2023Article
- Review of Case Reports on Adverse Events Related to Pre-workout Supplements Containing Synephrine.Cardiovascular toxicology · 2023Review
- Undeclared Doping Substances are Highly Prevalent in Commercial Sports Nutrition Supplements.Journal of sports science & medicine · 2021Article
- Description of Ventricular Arrhythmia after Taking Herbal Medicines in Middle-Aged Couples.Case reports in cardiology · 2020Article
- Severe Acute Hepatitis Attributed to the Herbal and Dietary Supplement OxyELITE Pro.Clinical liver disease · 2019Review
- Non-allowed Pharmacologically Active Substances in Physical and Sexual Performance Enhancing Products.Current neuropharmacology · 2017Article
- A Retrospective Study of Clinical Effects of Powdered Caffeine Exposures Reported to Three US Poison Control Centers.Journal of medical toxicology : official journal of the American College of Medical Toxicology · 2016Article
- Hepatotoxicity by Dietary Supplements: A Tabular Listing and Clinical Characteristics.International journal of molecular sciences · 2016Review
- Amphetamine Abuse Related Acute Myocardial Infarction.Case reports in cardiology · 2016Article
- Effects of controlled doses of Oxyelite Pro on physical performance in rats.Nutrition & metabolism · 2016Article
- Phytomelatonin: assisting plants to survive and thrive.Molecules (Basel, Switzerland) · 2015Review
- Abuse liability of the dietary supplement dimethylamylamine.Drug and alcohol dependence · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We describe the case of a previously healthy 22-year-old man who presented with anginal chest pain and was diagnosed with a non-ST-elevation myocardial infarction. For 3 weeks, he had been ingesting the dietary supplements Jack3d® (principal ingredient, 1,3-dimethylamylamine) and Phenorex™ (principal ingredient, Citrus aurantium) daily, before undertaking physical activity. Coronary angiograms revealed a proximal left anterior descending coronary artery thrombus with distal embolization. A combined medical regimen led to resolution of the thrombus. Three months later, the patient was asymptomatic with no evidence of ischemia. The primary ingredients in the sympathomimetic supplements taken by our patient are controversial in the medical community and have been individually associated with adverse cardiac events. There are no safety data on their simultaneous use. We discuss other reports of adverse effects associated with these supplements and recommend that the relevant safety guidelines be revised.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.