ArticleJournal of the American Geriatrics Society2014
Comorbidity burden and guideline-concordant care for breast cancer.
Article in Journal of the American Geriatrics Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.
- The Physical and Psychological Benefits of Nordic Walking in Patients with Breast Cancer: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Pooled it
- Impact of Comorbidities and Age on Cause-Specific Mortality in Postmenopausal Patients with Breast Cancer.The oncologist · 2019Trial
- Health services research in patients with breast cancer (CAMISS-prospective): study protocol for an observational prospective study.BMC cancer · 2018Trial
- Factors Associated With the Receipt of Female Breast Cancer Treatment Among People Living With Intellectual or Developmental Disabilities: A Population-Based Retrospective Cohort Study.Journal of intellectual disability research : JIDR · 2026Article
- Social wellbeing in older breast cancer survivors taking adjuvant endocrine therapy: impacts of self-efficacy for symptom management and pain.Frontiers in aging · 2026Article
- Concomitant medication, comorbidity and survival in patients with breast cancer.Nature communications · 2024Article
- Prospective Study of Incidence and Impact of Comorbidities on Breast Cancer Survival from India.Asian Pacific journal of cancer prevention : APJCP · 2023Observational
- Hospital Designations and Their Impact on Guideline-Concordant Care and Survival in Pancreatic Cancer. Do They Matter?Annals of surgical oncology · 2023Article
- Research Priorities for Interventions to Address Health Disparities in Lung Nodule Management: An Official American Thoracic Society Research Statement.American journal of respiratory and critical care medicine · 2023Article
- Guideline adherence and implementation of tumor board therapy recommendations for patients with gastrointestinal cancer.Journal of cancer research and clinical oncology · 2023Article
- Association between cognitive impairment and oral anticancer agent use in older patients with metastatic renal cell carcinoma.Journal of the American Geriatrics Society · 2022Article
- Article
- The Impact of Dementia on Cancer Treatment Decision-Making, Cancer Treatment, and Mortality: A Mixed Studies Review.JNCI cancer spectrum · 2021Review
- Examination of individual and multiple comorbid conditions and health-related quality of life in older cancer survivors.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2021Article
- Review
- A balancing act: racial disparities in cardiovascular disease mortality among women diagnosed with breast cancer.Annals of cancer epidemiology · 2020Article
- Association of Diabetes and Other Clinical and Sociodemographic Factors With Guideline-concordant Breast Cancer Treatment for Breast Cancer.American journal of clinical oncology · 2020Article
- A medicare-based comparative mortality analysis of active surveillance in older women with DCIS.NPJ breast cancer · 2020Article
- Impact of Guideline-Discordant Treatment on Cost and Health Care Utilization in Older Adults with Early-Stage Breast Cancer.The oncologist · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 8 institutions in 1 country.
Funding
Abstract
objectivesTo explore the relationship between level and type of comorbidity and guideline-concordant care for early-stage breast cancer.
designCross-sectional.
settingNational Program of Cancer Registry (NPCR) Breast and Prostate Cancer Patterns of Care study, which re-abstracted medical records from 2004 in seven cancer registries.
participantsIndividuals with stage 0-III breast cancer. MEASUREMENTS: Multicomponent guideline-concordant management was modeled based on tumor size, node status, and hormone receptor status, according to consensus guidelines. Comorbid conditions and severity were measured using the Adult Comorbidity Evaluation Index (ACE-27). Multivariate logistic regression models determined factors associated with guideline-concordant care and included overall ACE-27 scores and 26 separate ACE comorbidity categories, age, race, stage, and source of payment.
resultsThe study sample included 6,439 women (mean age 58.7, range 20-99; 76% white; 44% with no comorbidity; 70% estrogen- or progesterone-receptor positive, or both; 31% human epidermal growth factor receptor 2 positive). Care was guideline concordant in 60%. Guideline concordance varied according to overall comorbidity burden (70% for none; 61% for minor; 58% for moderate, 43% for severe; P < .05). In multivariate analysis, the presence of hypertension (odds ratio (OR) = 1.15, 95% confidence interval (CI) = 1.01-1.30) predicted guideline concordance, whereas dementia (OR = 0.45, 95% CI = 0.24-0.82) predicted lack of guideline concordance. Older age (≥ 50) and black race were associated with less guideline concordance, regardless of comorbidity level.
conclusionWhen reporting survival outcomes in individuals with breast cancer with comorbidity, adherence to care guidelines should be among the covariates.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.