ArticleBiochemistry2014
Interactions of indocyanine green and lipid in enhancing near-infrared fluorescence properties: the basis for near-infrared imaging in vivo.
Article in Biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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The trial behind it
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Who cites it
83 citing papers in PubMed, 154 citations in OpenAlex.
- Preclinical Imaging for the Translation of Innovative Nutritional Strategies: Current Applications and Future Perspectives.Journal of imaging · 2026Review
- Intraoperative indocyanine green (ICG) fluorescence to assess mucosal integrity during laparoscopic Heller-Dor surgery: a pilot randomized study.Updates in surgery · 2026Article
- Cholesterol and Albumin as Key Modulators of ICG Photostability in Aqueous Solution.Molecules (Basel, Switzerland) · 2026Article
- Indocyanine green excitation-emission matrix characterization: excitation-dependent emission shifts and application-specific spectra.Journal of biomedical optics · 2026Article
- Harnessing Supramolecular J-Aggregates in Deep Eutectic Solvents for Tunable NIR Photothermal and Photodynamic Therapy.Nano letters · 2026Article
- Lighting the path: a narrative review of non-molecular intraoperative lung imaging modalities.Journal of thoracic disease · 2026Review
- Fluorescence Imaging of DMDG-ICG Across NIR-I and NIR-II Windows Using a Single-Camera System.International journal of molecular sciences · 2026Article
- Optimization of Intraoperative Near-Infrared Fluorescence Mapping with Indocyanine Green for Sentinel Lymph Node Detection in Cervical and Endometrial Cancer.Pharmaceutics · 2026Article
- Near-infrared imaging of intraperitoneal ovarian cancer enhanced by BrCy112 in a dual mode (MR and NIR), dual-Gd nanoparticle.Nanoscale · 2025Article
- Indocyanine green excitation-emission matrix characterization: excitation-dependent emission shifts and application-specific spectra.bioRxiv : the preprint server for biology · 2025Article
- Indocyanine green (ICG) enhances penetration of 1300 nm optical coherence tomography imaging forOptics letters · 2025Article
- Improving vascular retention of indocyanine green forJournal of biomedical optics · 2025Article
- TMTP1-modified polymeric micelles for the inhibition of ovarian cancer metastasis and recurrence through enhanced photothermal-immunotherapy.Materials today. Bio · 2025Article
- Advances in molecular imaging and targeted therapeutics for lymph node metastasis in cancer: a comprehensive review.Journal of nanobiotechnology · 2024Review
- Nano-fluorescence imaging: advancing lymphatic disease diagnosis and monitoring.Nano convergence · 2024Review
- Indocyanine Green-Labeled Platelets for Survival and Recovery Studies.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2024Article
- Optimizing Indocyanine Green Dosage for Near-Infrared Fluorescence Perfusion Assessment in Bowel Anastomosis: A Prospective, Systematic Dose-Ranging Study.Life (Basel, Switzerland) · 2024Article
- Development of Robust Cationic Light-Activated Thermosensitive Liposomes: Choosing the Right Lipids.Molecular pharmaceutics · 2023Article
- Development of novel tracers for sentinel node identification in cervical cancer.Cancer science · 2023Article
- Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Indocyanine green (ICG) is a near-infrared (NIR) contrast agent commonly used for in vivo cardiovascular and eye imaging. For medical diagnosis, ICG is limited by its aqueous instability, concentration-dependent aggregation, and rapid degradation. To overcome these limitations, scientists have formulated ICG in various liposomes, which are spherical lipid membrane vesicles with an aqueous core. Some encapsulate ICG, while others mix it with liposomes. There is no clear understanding of lipid-ICG interactions. Therefore, we investigated lipid-ICG interactions by fluorescence and photon correlation spectroscopy. These data were used to design stable and maximally fluorescent liposomal ICG nanoparticles for NIR optical imaging of the lymphatic system. We found that ICG binds to and is incorporated completely and stably into the lipid membrane. At a lipid:ICG molar ratio of 250:1, the maximal fluorescence intensity was detected. ICG incorporated into liposomes enhanced the fluorescence intensity that could be detected across 1.5 cm of muscle tissue, while free ICG only allowed 0.5 cm detection. When administered subcutaneously in mice, lipid-bound ICG in liposomes exhibited a higher intensity, NIR image resolution, and enhanced lymph node and lymphatic vessel visualization. It also reduced the level of fluorescence quenching due to light exposure and degradation in storage. Lipid-bound ICG could provide additional medical diagnostic value with NIR optical imaging for early intervention in cases of lymphatic abnormalities.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.