ArticlePflugers Archiv : European journal of physiology1988
Calcium dependent gating of the L-glutamate activated, excitatory synaptic channel on crayfish muscle.
Article in Pflugers Archiv : European journal of physiology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Calcium currents, transmitter release and facilitation of release at voltage-clamped crayfish nerve terminals.The Journal of physiology · 1996Article
- A voltage-sensitive cation channel present in clusters in lobster skeletal muscle membrane.The Journal of membrane biology · 1994Article
- Dual regulation of cation-selective channels by muscarinic and alpha 1-adrenergic receptors in the rabbit portal vein.The Journal of physiology · 1993Article
- GABA-gated anion channels in intact crayfish opener muscle fibres and stretch-receptor neurons are neither activated nor desensitized by glutamate.Journal of comparative physiology. A, Sensory, neural, and behavioral physiology · 1992Article
- Effect of external Cd2+ and other divalent cations on carbachol-activated non-selective cation channels in guinea-pig ileum.The Journal of physiology · 1991Article
- Evoked phasic release in frog nerve terminals obtained after block of Ca2+ entry by Cd2+.Pflugers Archiv : European journal of physiology · 1991Article
- Effect of membrane potential on acetylcholine-induced inward current in guinea-pig ileum.The Journal of physiology · 1990Article
- Rapid activation, desensitization, and resensitization of synaptic channels of crayfish muscle after glutamate pulses.Biophysical journal · 1990Article
- Inhibition of Ca2+ inflow at nerve terminals of frog muscle blocks facilitation while phasic transmitter release is still considerable.Pflugers Archiv : European journal of physiology · 1990Article
- Calcium dependence of quantal release triggered by graded depolarization pulses to nerve terminals on crayfish and frog muscle.Pflugers Archiv : European journal of physiology · 1989Article
- Twin pulse facilitation in dependence on pulse duration and calcium concentration at motor nerve terminals of crayfish and frogs.Pflugers Archiv : European journal of physiology · 1989Article
- Calcium and depolarization dependence of twin-pulse facilitation of synaptic release at nerve terminals of crayfish and frog muscle.Pflugers Archiv : European journal of physiology · 1989Article
- Membrane depolarization evokes neurotransmitter release in the absence of calcium entry.Nature · 1989Article
- Spontaneous and evoked quantal neurotransmitter release at the neuromuscular junction of the larval housefly, Musca domestica.Pflugers Archiv : European journal of physiology · 1989Article
- Ionic permeabilities of L-glutamate activated, excitatory synaptic channel in crayfish muscle.Pflugers Archiv : European journal of physiology · 1988Article
- Acetylcholine activates a chloride channel as well as glutamate and GABA.Journal of comparative physiology. A, Sensory, neural, and behavioral physiology · 1988Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Excitatory, glutamate-activated single channel currents were measured in outside-out patches of crayfish muscle. The open times of single channel openings, and the durations and rates of bursts were evaluated. These kinetic parameters were not appreciably affected by replacement of extracellular Na+ by Li+ or choline. Changes in extracellular Ca2+ concentration Cao also did not influence the duration of single openings. However the mean burst duration decreased for Cao less than 13.5 mM and the rate of bursts declined with a power of almost 2 in low Cao. At Cao less than 1 mM practically no channel openings were observed in presence of glutamate. In order to exclude more rapid desensitization of the glutamate receptors in low Cao as the cause of disappearance of channel openings, glutamate was applied in short pulses with a liquid-filament switch. In 0 Cao also a glutamate pulse did not trigger channel openings. In presence of 13.5mM Cao, the inorganic Ca-channel blockers La3+ and Cd2+ diminished the duration and rate of bursts of channel openings in a similar manner as low Cao. The effects of low Cao and of Cd2+ were tested also on quantal postsynaptic currents, EPSCs, which were recorded through a perfused macro-patch-clamp electrode. At 1.4 mM Cao in the perfused electrode tip, spontaneous EPSCs were reduced at least by a factor of 4, and elicited EPSCs by a factor of 16. Application of Cd2+ had similarly strong effects on the EPSCs. Also the decay of EPSCs was shortened substantially in 1.4 mM Cao or 5 mM Cd2+. The inhibitory Cl(-)-channel of crayfish muscle, activated by glutamate or GABA, also was studied in outside-out patches. The openings of this channel persisted in 0 Cao solutions; the block of channel openings in low Cao thus is a specific property of the excitatory channel. The action of Cao on the excitatory channel may be described as that of a cofactor to glutamate. A possible reaction scheme is proposed.
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