ArticleAdvanced pharmaceutical bulletin2014
Modifications to the conventional nanoprecipitation technique: an approach to fabricate narrow sized polymeric nanoparticles.
Article in Advanced pharmaceutical bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed.
- Carbon and Cellulose-Based Nanoparticle-Reinforced Polymer Nanocomposites: A Critical Review.Nanomaterials (Basel, Switzerland) · 2023Review
- Exploring Various Techniques for the Chemical and Biological Synthesis of Polymeric Nanoparticles.Nanomaterials (Basel, Switzerland) · 2022Review
- Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2.Journal of controlled release : official journal of the Controlled Release Society · 2021Review
- Polymeric Nanoparticles: Production, Characterization, Toxicology and Ecotoxicology.Molecules (Basel, Switzerland) · 2020Review
- Fabrication and optimization of camptothecin loaded Eudragit S 100 nanoparticles by Taguchi L4 orthogonal array design.International journal of pharmaceutical investigationArticle
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeNanoprecipitation is the convenient and commonly used method for the preparation of polymeric nanoparticles around 170 nm but yield particles with broad distribution, which require filtration step to produce particles with narrow distribution. Hence, the primary aim of the present study was to implement few modifications to the conventional nanoprecipitation method to reduce the mean particle size less than 150 nm and to produce particles with narrow distribution without filtration step.
methodsEudragit E 100 nanoparticles were prepared using modified nanoprecipitation method 1 and 2. Prepared nanoparticles were characterized for the mean particle size, surface area and uniformity.
resultsEudragit E 100 nanoparticles prepared using modified nanoprecipitation method 1 has shown a mean particle size of 196 nm with surface area of 50.9 m(2)g(-1) and uniformity of 0.852 whereas, Eudragit E 100 nanoparticles prepared using modified nanoprecipitation method 2 has shown a mean particle size of 114 nm with surface area of 57.9 m(2)g(-1) and uniformity of 0.259.
conclusionModification to the conventional nanoprecipitation method (method 2) has produced mean particle size less than 150 nm and produced nanoparticles with narrow distribution without filtration step.
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