ArticleMolecular and cellular biology1988
A group of type I keratin genes on human chromosome 17: characterization and expression.
Article in Molecular and cellular biology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 141 citations in OpenAlex.
- Pathophysiology of pachyonychia congenita-associated palmoplantar keratoderma: new insights into skin epithelial homeostasis and avenues for treatment.The British journal of dermatology · 2020Review
- Reorganization of the interchromosomal network during keratinocyte differentiation.Chromosoma · 2016Article
- Transcriptome and ultrastructural changes in dystrophic Epidermolysis bullosa resemble skin aging.Aging · 2015Article
- A splice variant in KRT71 is associated with curly coat phenotype of Selkirk Rex cats.Scientific reports · 2013Article
- Host regulatory network response to infection with highly pathogenic H5N1 avian influenza virus.Journal of virology · 2011Article
- The naked truth: Sphynx and Devon Rex cat breed mutations in KRT71.Mammalian genome : official journal of the International Mammalian Genome Society · 2010Article
- Comparative genomics of the keratin-associated protein (KAP) gene clusters in human, chimpanzee, and baboon.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Keith R. Porter Lecture, 1996. Of mice and men: genetic disorders of the cytoskeleton.Molecular biology of the cell · 1997Review
- Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: defining a potential role for keratin 16.The Journal of cell biology · 1996Article
- The basal keratin network of stratified squamous epithelia: defining K15 function in the absence of K14.The Journal of cell biology · 1995Article
- Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin.The Journal of cell biology · 1994Article
- The genetic basis of Weber-Cockayne epidermolysis bullosa simplex.Proceedings of the National Academy of Sciences of the United States of America · 1993Article
- Linkage of epidermolysis bullosa simplex to keratin gene loci.Journal of medical genetics · 1992Article
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1992Review
- Mouse chromosome 11.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- Comparative map for mice and humans.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Review
- An ultrahigh-sulphur keratin gene of the human hair cuticle is located at 11q13 and cross-hybridizes with sequences at 11p15.Mammalian genome : official journal of the International Mammalian Genome Society · 1991Article
- Epidermal differentiation: the bare essentials.The Journal of cell biology · 1990Review
- TGF-beta and retinoic acid: regulators of growth and modifiers of differentiation in human epidermal cells.Cell regulation · 1990Article
- Localisation of a cDNA clone for human cytokeratin 18 to chromosome 17p11-p12 by in situ hybridisation.Human genetics · 1990Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The human type I keratins K16 and K14 are coexpressed in a number of epithelial tissues, including esophagus, tongue, and hair follicles. We determined that two genes encoding K16 and three genes encoding K14 were clustered in two distinct segments of chromosome 17. The genes within each cluster were tightly linked, and large parts of the genome containing these genes have been recently duplicated. The sequences of the two K16 genes showed striking homology not only within the coding sequences, but also within the intron positions and sequences and extending at least 400 base pairs 5' upstream and 850 base pairs 3' downstream from these genes. Despite the strong homologies between these two genes, only one of the genes encoded a protein which assembled into keratin filaments when introduced into simple epithelial cells. While there were no obvious abnormalities in the sequence of the other gene, its promoter seemed to be significantly weaker, and even a hybrid gene with the other gene's promoter gave rise to a much reduced mRNA level after gene transfection. To demonstrate that the functional K16 gene that we identified was in fact responsible for the K16 expressed in human tissues, we made a polyclonal antiserum which recognized our functional K16 gene product in both denatured and filamentous form and which was specific for bona fide human K16.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.