Evidence map›Paper›PMID 24510891›Full record

ArticleCurrent protocols in microbiology2013

Newcastle disease virus-like particles: preparation, purification, quantification, and incorporation of foreign glycoproteins.

Lori W McGinnes, Trudy G Morrison

Open access · greenAbstract read
In one paragraph

Article in Current protocols in microbiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 32 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Lori W McGinnesDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts.
Trudy G MorrisonDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts.
University of Massachusetts Chan Medical School · US

Funding

Technologies for Human Cellular ImmunologyU19AI057319 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI FINBERG, ROBERT WILLIAM · 2003 to 2013
$34.4M
PARAMYXOVIRUS MEMBRANE FUSIONR01AI030572 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MORRISON, TRUDY G. · 1991 to 2005
$1.6M
Humoral Immune Responses to Virus-like Particle Vaccine Candidates for RSVR56AI093791 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MORRISON, TRUDY G. · 2011 to 2011
$411k
Paramyxovirus EntryR21AI030572 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MORRISON, TRUDY G. · 2001 to 2001
$315k
NIAID NIH HHS AI093791NIAID NIH HHS AI30572NIAID NIH HHS R01 AI030572NIAID NIH HHS R21 AI030572NIAID NIH HHS R56 AI093791NIAID NIH HHS U19 AI057319NIAID NIH HHS U19AI057319
6 · The paper itself

Abstract

Virus-like particles (VLPs) are large particles, the size of viruses, composed of repeating structures that mimic those of infectious virus. Since their structures are similar to that of viruses, they have been used to study the mechanisms of virus assembly. They are also in development for delivery of molecules to cells and in studies of the immunogenicity of particle-associated antigens. However, they have been most widely used for development of vaccines and vaccine candidates. VLPs can form upon the expression of the structural proteins of many different viruses. This chapter describes the generation and purification of VLPs formed with the structural proteins, M, NP, F, and HN proteins, of Newcastle disease virus (NDV). Newcastle disease virus-like particles (ND VLPs) have also been developed as a platform for assembly into VLPs of glycoproteins from other viruses. This chapter describes the methods for this use of ND VLPs.

Indexed as

Genetic VectorsDrug CarriersGlycoproteinsNewcastle disease virusRecombinant ProteinsVaccines, Virus-Like ParticleVirosomesDrug CarriersGlycoproteinsRecombinant ProteinsVaccines, Virus-Like ParticleVirosomeschimera glycoproteinsNewcastle disease virusparamyxovirusvirus-like particles

Identifiers

PMID24510891
PMCPMC4036627
OpenAlexW1493152336

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.