Evidence map›Paper›PMID 24510791›Full record

ArticleCurrent protocols in stem cell biology2013

Intraspinal transplantation of mouse and human neural precursor cells.

Jason G Weinger, Lu Chen, Ronald Coleman, Ronika Leang, Warren C Plaisted, Jeanne F Loring, Thomas E Lane

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current protocols in stem cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jason G WeingerDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, California.
Lu ChenDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, California.
Ronald ColemanCenter for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California.
Ronika LeangDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, California.
Warren C PlaistedDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, California.
Jeanne F LoringCenter for Regenerative Medicine, Department of Chemical Physiology, The Scripps Research Institute, La Jolla, California.
Thomas E LaneDepartment of Molecular Biology and Biochemistry, Sue and Bill Gross Stem Cell Center, Multiple Sclerosis Research Center, University of California, Irvine, California.
University of California, Irvine · USScripps Research Institute · US

Funding

Viral-induced demyelination and neural stem cell-mediated remyelinationR01NS074987 · NINDS · UNIVERSITY OF UTAH · PI LANE, THOMAS E · 2011 to 2015
$1.6M
NINDS NIH HHS 1R01 NS074987NINDS NIH HHS R01 NS074987
6 · The paper itself

Abstract

This unit describes the preparation and transplantation of human neural precursor cells (hNPCs) and mouse neural precursor cells (mNPCs) into the thoracic region of the mouse spinal cord. The techniques in this unit also describe how to prepare the mouse for surgery by performing a laminectomy to expose the spinal cord for transplantation. NPCs genetically labeled with eGFP transplanted into the spinal cord of a mouse following viral-mediated demyelination can efficiently be detected via eGFP expression. Transplantation of these cells into the spinal cord is an efficacious way to determine their effects in neurological disorders such as multiple sclerosis, Alzheimer's disease, and spinal cord injury.

Indexed as

AnimalsGreen Fluorescent ProteinsHumansMiceNeural Stem CellsSpinal CordStem Cell TransplantationGreen Fluorescent Proteinshuman neural precursor cellsintraspinal transplantationlaminectomymouse neural precursor cellsmultipotency

Identifiers

PMID24510791
PMCPMC3920297
OpenAlexW1864440508

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.