ArticleJournal of nephrology2014
Netrin-1, a urinary proximal tubular injury marker, is elevated early in the time course of human diabetes.
Article in Journal of nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Urinary and circulatory netrin-1 as biomarker in diabetes and its related complications: a systematic review and meta-analysis.Endocrine · 2024Pooled it
- Utility of urinary netrin-1 levels in patients with type 2 diabetic nephropathy and its correlation with renal function.BMC endocrine disorders · 2025Article
- Microbiota and Inflammatory Markers: A Review of Their Interplay, Clinical Implications, and Metabolic Disorders.International journal of molecular sciences · 2025Review
- Insulin restores renal neprilysin (NEP) and attenuates the shedding of urinary NEP and KIM-1 in diabetic Akita mice.Frontiers in pharmacology · 2025Article
- TCF3 downregulation alleviates renal fibrosis via PI3K/Akt/mTOR pathway inhibition and autophagy restoration in diabetic nephropathy.Frontiers in medicine · 2025Article
- New Markers of Early Kidney Damage in Children and Adolescents with Simple Obesity.International journal of molecular sciences · 2024Article
- Review of potential biomarkers of inflammation and kidney injury in diabetic kidney disease.Diabetes/metabolism research and reviews · 2022Review
- Neogenin pathway positively regulates fibronectin production by glomerular mesangial cells.American journal of physiology. Cell physiology · 2022Article
- Early renal structural changes and potential biomarkers in diabetic nephropathy.Frontiers in physiology · 2022Review
- Is Urinary Netrin-1 a Good Marker of Tubular Damage in Preterm Newborns?Journal of clinical medicine · 2021Article
- Kidney Diseases: The Age of Molecular Markers.Advances in experimental medicine and biology · 2021Article
- Urinary netrin-1 concentration in healthy full-term newborns.Archives of medical science : AMS · 2021Article
- Netrin-1 works with UNC5B to regulate angiogenesis in diabetic kidney disease.Frontiers of medicine · 2020Article
- Netrin as a Novel Biomarker and Its Therapeutic Implications in Diabetes Mellitus and Diabetes-Associated Complications.Journal of diabetes research · 2018Review
- Relationship Between Circulating Netrin-1 Concentration, Impaired Fasting Glucose, and Newly Diagnosed Type 2 Diabetes.Frontiers in endocrinology · 2018Article
- Evaluation of Netrin-1 Levels and Albuminuria in Patients With Diabetes.Journal of clinical laboratory analysis · 2016Article
- Urinary Netrin-1: A New Biomarker for the Early Diagnosis of Renal Damage in Obese Children.Journal of clinical research in pediatric endocrinology · 2016Article
- Low-Dose IL-17 Therapy Prevents and Reverses Diabetic Nephropathy, Metabolic Syndrome, and Associated Organ Fibrosis.Journal of the American Society of Nephrology : JASN · 2016Article
- Novel biomarkers for early diagnosis of acute kidney injury after cardiac surgery in adults.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2016Article
- Guidance cue netrin-1 and the regulation of inflammation in acute and chronic kidney disease.Mediators of inflammation · 2014Review
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundNetrin-1 was recently identified as an early diagnostic biomarker of chronic kidney disease (CKD) in an experimental animal model. However, its usefulness for early diagnosis of CKD in humans is unknown. The current study evaluated whether netrin-1 is increased in urine from human diabetic patients.
methodsSpot urine samples from healthy volunteers, diabetes without microalbuminuria, diabetes with microalbuminuria and diabetes with macroalbuminuria were collected after receiving consent. Netrin-1 in urine was quantified by enzyme-linked immunosorbent assay and the data analyzed to determine whether urinary netrin-1 significantly correlates with disease progression.
resultsUrinary netrin-1 levels were significantly increased in normoalbuminuric diabetic patients compared to healthy controls, and still further elevated in patients with microalbuminuria and overt nephropathy. Urinary netrin-1 was significantly associated with albuminuria and estimated glomerular filtration rate, independently of age and sex.
conclusionNetrin-1 is detectable in urine from diabetic patients and may serve as a useful early diagnostic biomarker predicting the development of CKD in diabetes.
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