ArticleEnvironmental science and pollution research international2014
Genotoxicity of oxy-PAHs to Japanese medaka (Oryzias latipes) embryos assessed using the comet assay.
Article in Environmental science and pollution research international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 57 citations in OpenAlex.
- Oxygenated PAHs in Tokyo Bay sediments: distributional contrast with parent PAHs and their effect evaluations with fish embryos.Environmental monitoring and assessment · 2026Article
- A review of food contamination with nitrated and oxygenated polycyclic aromatic hydrocarbons: toxicity, analysis, occurrence, and risk assessment.Food science and biotechnology · 2024Review
- Carbon-based adsorbents for the mitigation of polycyclic aromatic hydrocarbon: a review of recent research.Environmental geochemistry and health · 2024Review
- Oxidation 1-methyl naphthalene based on the synergy of environmentally persistent free radicals (EPFRs) and PAHs in particulate matter (PM) surface.Chemosphere · 2023Article
- Evaluation of Environmentally Relevant Nitrated and Oxygenated Polycyclic Aromatic Hydrocarbons in Honey.Foods (Basel, Switzerland) · 2023Article
- Chemical Contamination in Bread from Food Processing and Its Environmental Origin.Molecules (Basel, Switzerland) · 2022Review
- Effects of benzo[a]pyrene exposure on black rockfish (Sebastes schlegelii): EROD activity, CYP1A protein, and immunohistochemical and histopathological alterations.Environmental science and pollution research international · 2022Article
- The effects of polycyclic aromatic compounds (PACs) on mammalian ovarian function.Current research in toxicology · 2022Article
- Effects of 9,10-phenanthrenequione on antioxidant indices and metabolite profiles inRoyal Society open science · 2020Article
- Distribution of petrogenic polycyclic aromatic hydrocarbons (PAHs) in seafood following Deepwater Horizon oil spill.Marine pollution bulletin · 2019Article
- Oxygenated polycyclic aromatic hydrocarbons in mussels: analytical method development and occurrence in the Belgian coastal zone.Environmental science and pollution research international · 2019Article
- Effects of oxygenated polycyclic aromatic hydrocarbons on the early life stages of Japanese medaka.Environmental science and pollution research international · 2017Article
- Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons.Toxicology research · 2016Article
- PAHs and fish--exposure monitoring and adverse effects--from molecular to individual level.Environmental science and pollution research international · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polycyclic aromatic hydrocarbons (PAHs) have long been recognized as important environmental toxicants. Despite a plethora of information on the fate and effects of parent PAHs, relatively little is known about the environmental fate and toxicity of ketone- and quinone-substituted PAH oxidation products (termed oxy-PAHs), particularly in the aquatic environment. This study begins to fill that gap using embryos of the Japanese medaka (Oryzias latipes) as a model species. The genotoxic potential of two environmentally relevant oxy-PAHs, acenaphthenequinone and 7,12-benz[a]anthracenquinone, was assessed using the comet assay. We found that both oxy-PAHs could cause significant increases in DNA damage after only 48 h of exposure at the lowest concentrations tested (5 μg/L). Comparisons of the genotoxic potential between these oxy-PAHs and their corresponding parent PAHs (acenaphthene and benz[a]anthracene) and a well-known mutagenic PAH, benzo[a]pyrene, indicated similar potencies among all five of these compounds, particularly after longer (7 day) exposures. This study demonstrates the mutagenic potential of oxy-PAHs to an in vivo fish embryo model and points out the need for further study of their environmental occurrence and biologic effects.
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