ArticleGenes & nutrition2014
S-Adenosyl methionine synthetase 1 limits fat storage in Caenorhabditis elegans.
Article in Genes & nutrition, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Citrulline drives age-related lipid deposition for healthspan.Nature communications · 2026Article
- Aging-associated decline of phosphatidylcholine synthesis is a malleable trigger of natural mitochondrial aging.Nature communications · 2026Article
- Coffee Silverskin Supplementation Alleviates High-Glucose-Diet-Induced Obesity by Modulating Lipogenic Gene Expression inMolecules (Basel, Switzerland) · 2026Article
- Profiling the compendium of changes in Saccharomyces cerevisiae due to mutations that alter availability of the main methyl donor S-Adenosylmethionine.G3 (Bethesda, Md.) · 2024Article
- SAMS-1 is required for the normal defecation motor program inmicroPublication biology · 2024Article
- Application ofInternational journal of molecular sciences · 2023Review
- S-Adenosylmethionine Synthetase Is Required for Cell Growth, Maintenance of G0 Phase, and Termination of Quiescence in Fission Yeast.iScience · 2018Article
- Lipid and Carbohydrate Metabolism inGenetics · 2017Review
- MIP-MAP: High-Throughput Mapping ofGenetics · 2017Article
- A Genetic Screen for Mutants with Supersized Lipid Droplets in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2016Article
- Article
- Methyl group donors abrogate adaptive responses to dietary restriction in C. elegans.Genes & nutrition · 2016Article
- Metabolome and proteome changes with aging in Caenorhabditis elegans.Experimental gerontology · 2015Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytosolic lipid droplets are versatile, evolutionarily conserved organelles that are important for the storage and utilization of lipids in almost all cell types. To obtain insight into the physiological importance of lipid droplet size, we isolated and characterized a new S-adenosyl methionine synthetase 1 (SAMS-1)-deficient Caenorhabditis elegans mutant, which have enlarged lipid droplets throughout its life cycle. We found that the sams-1 mutant showed a markedly reduced body size and progeny number; impaired synthesis of phosphatidylcholine, a major membrane phospholipid; and elevated expression of key lipogenic genes, such as dgat-2, resulting in the accumulation of triacylglyceride in fewer, but larger, lipid droplets. The sams-1 mutant store more than 50 % (wild type: 10 %) of its intestinal fat in large lipid droplets, ≥10 μm(3) in size. In response to starvation, SAMS-1 deficiency causes reduced depletion of a subset of lipid droplets located in the anterior intestine. Given the importance of liberation of fatty acids from lipid droplets, we propose that the physiological function of SAMS-1, a highly conserved enzyme involved in one-carbon metabolism, is the limitation of fat storage to ensure proper growth and reproduction.
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Registered trials
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