SynthesisIrish journal of medical science2014
Increased leptin levels in patients with rheumatoid arthritis: a meta-analysis.
Synthesis in Irish journal of medical science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 24 citations in OpenAlex.
- Visceral adipose tissue is related to interleukin 6 and resistin in juvenile idiopathic arthritis - a case-control study.Rheumatology international · 2025Article
- Review
- The Influence of Adipokines on Radiographic Damage in Inflammatory Rheumatic Diseases.Biomedicines · 2023Review
- The Involvement of Glucose and Lipid Metabolism Alteration in Rheumatoid Arthritis and Its Clinical Implication.Journal of inflammation research · 2023Review
- Tocilizumab Increases Body Weight and Serum Adipokine Levels in Patients with Rheumatoid Arthritis Independently of Their Treatment Response: a Retrospective Cohort Study.Journal of Korean medical science · 2020Article
- Leptin as an open secret in the physiopathology of rheumatic diseases.Clinical rheumatology · 2020Article
- Mini-Review: The Contribution of Adipokines to Joint Inflammation in Inflammatory Rheumatic Diseases.Frontiers in endocrinology · 2020Review
- Effects of Tocilizumab, an Anti-Interleukin-6 Receptor Antibody, on Serum Lipid and Adipokine Levels in Patients with Rheumatoid Arthritis.International journal of molecular sciences · 2019Article
- Leptin as an obesity marker in rheumatoid arthritis.Rheumatology international · 2018Article
- Adipokines in bone disease.Nature reviews. Rheumatology · 2016Review
- Serum leptin and serum leptin/serum leptin receptor ratio imbalance in obese rheumatoid arthritis patients positive for anti-cyclic citrullinated peptide antibodies.Arthritis research & therapy · 2015Article
- Serum leptin levels in pemphigus: a case control study.BioMed research international · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimPublished data regarding the association of leptin levels with rheumatoid arthritis (RA) are contradictory. To derive a more precise estimation of this relationship, a meta-analysis was performed.
methodsPublished literature from PubMed, Embase and Cochrane Library was obtained. Pooled standard mean difference (SMD) with 95 % confidence interval (CI) was calculated using fixed-effects or random-effect model analysis. Heterogeneity among studies was evaluated using the Cochran Q and I (2) statistics. The study quality was assessed by the Newcastle-Ottawa scale.
resultsA total of 20 studies including 998 RA patients and 692 controls were finally included in the meta-analysis. Compared to healthy controls, RA patients had significantly higher leptin levels (SMD 1.19, 95 % CI 0.59-1.79). Subgroup analyses showed that region, race, age, body mass index (BMI), disease duration and disease activity were positively associated with plasma leptin levels in RA patients. Sensitivity analysis showed no significant change when any one study was excluded. Publication bias was also undetected.
conclusionsThe present meta-analysis suggested that leptin levels were higher in RA patients than those in healthy controls, which may be subject to different region, race, age, BMI, disease duration and disease activity.
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Registered trials
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