ArticleCancer2014
Contemporary prevalence of pretreatment urinary, sexual, hormonal, and bowel dysfunction: Defining the population at risk for harms of prostate cancer treatment.
Article in Cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03009123 (Erectile Dysfunction and the Future Risk of Prostate Cancer), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Erectile Dysfunction and the Future Risk of Prostate Cancer: a Population-based Longitudinal Follow-up Study With Concurrent Double Comparison Cohorts
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Patient-reported outcomes in the ProtecT randomized trial of clinically localized prostate cancer treatments: study design, and baseline urinary, bowel and sexual function and quality of life.BJU international · 2016Trial
- Patient-reported functional outcome measures and treatment choice for prostate cancer.BMC urology · 2022Article
- Age-stratified outcomes after radical prostatectomy in a randomized setting (LAP-01): do younger patients have more to lose?World journal of urology · 2022Article
- Impact of Age on Patient-Reported Outcomes Following Stereotactic Body Radiation Therapy for Prostate Cancer.Cureus · 2021Article
- Determinants of self-reported functional status (EPIC-26) in prostate cancer patients prior to treatment.World journal of urology · 2021Article
- Radiotherapy after radical prostatectomy: Effect of timing of postprostatectomy radiation on functional outcomes.Urologic oncology · 2020Observational
- Baseline patient reported outcomes data shows high prevalence of overactive bladder, sexual dysfunction, depression and anxiety in Canadian men with newly diagnosed localized prostate cancer.Translational andrology and urology · 2020Article
- A prospective study of patient reported urinary incontinence among American, Norwegian and Spanish men 1 year after prostatectomy.Asian journal of urology · 2020Article
- Interpretation of Domain Scores on the EPIC-How Does the Domain Score Translate into Functional Outcomes?The Journal of urology · 2019Observational
- Comparison of Patient-reported Outcomes After External Beam Radiation Therapy and Combined External Beam With Low-dose-rate Brachytherapy Boost in Men With Localized Prostate Cancer.International journal of radiation oncology, biology, physics · 2018Article
- Older Age, Early Symptoms and Physical Function are Associated with the Severity of Late Symptom Clusters for Men Undergoing Radiotherapy for Prostate Cancer.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2018Article
- Racial and Ethnic Variation in Health-Related Quality of Life Scores Prior to Prostate Cancer Treatment.Sexual medicine · 2017Article
- Treatment Decision Regret Among Long-Term Survivors of Localized Prostate Cancer: Results From the Prostate Cancer Outcomes Study.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2017Article
- Article
- Cancer Related Fatigue and Quality of Life in Patients with Advanced Prostate Cancer Undergoing Chemotherapy.BioMed research international · 2016Article
- Changes in Nocturia and Lower Urinary Tract Symptoms after Radical Prostatectomy.The world journal of men's health · 2015Article
- A Longitudinal Study of Predictors of Sexual Dysfunction in Men on Active Surveillance for Prostate Cancer.Sexual medicine · 2015Article
- Influence of radical prostatectomy for prostate cancer on work status and working life 3 years after surgery.Journal of cancer survivorship : research and practice · 2015Article
- Dosimetric benefits of hemigland stereotactic body radiotherapy for prostate cancer: implications for focal therapy.The British journal of radiology · 2015Article
Corrections and comments
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Authors and funding
16 authors at 9 institutions in 1 country.
Funding
Abstract
backgroundThe authors investigated the prevalence of pretreatment urinary, sexual, hormonal, and bowel dysfunction in a contemporary, population-based prostate cancer cohort. They also explored the associations between baseline function and age, comorbidity, and timing of baseline survey completion with respect to treatment.
methodsThe Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study is a population-based, prospective cohort study that enrolled 3691 men with incident prostate cancer during 2011 and 2012. Pretreatment function was ascertained using the Expanded Prostate Cancer Index-26 (EPIC-26). Data were stratified by age, comorbidity, and timing of baseline survey completion with respect to treatment. Unadjusted and multivariable linear regression analyses were performed to evaluate the relations between exposures and pretreatment function.
resultsAfter applying exclusion criteria, the study cohort comprised 3072 men. A strikingly high proportion of men reported inability to obtain erections satisfactory for intercourse (45%) and some degree of urinary incontinence (17%) at baseline. Sexual function was particularly age-sensitive, with patients aged ≤60 years reporting summary scores in excess of 30 points higher than patients aged ≥75 years (P < .001). Compared with the healthiest men, highly comorbid patients reported less favorable function in each domain, including urinary incontinence (summary score, 89.5 vs 74.1; P < .001) and sexual function (summary score, 70.8 vs 32.9; P < .001). Although statistically significant differences in summary scores were identified between patients who completed the baseline questionnaire before treatment (52%) versus after treatment (48%), the absolute differences were small (range, 1-3 points).
conclusionsPatients with newly diagnosed prostate cancer exhibit a wide distribution of pretreatment function. The current data may be used to redefine the population "at risk" for treatment-related harms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.