ArticleClinical orthopaedics and related research2014
Antimicrobial distribution from local delivery depends on dose : a pilot study with MRI.
Article in Clinical orthopaedics and related research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
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- Adjuvant antibiotic-loaded bone cement: Concerns with current use and research to make it work.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Temperature-responsive PNDJ hydrogels provide high and sustained antimicrobial concentrations in surgical sites.Drug delivery and translational research · 2019Article
- Investigation of strontium transport and strontium quantification in cortical rat bone by time-of-flight secondary ion mass spectrometry.Journal of the Royal Society, Interface · 2019Article
- Biofilm Antimicrobial Susceptibility Increases With Antimicrobial Exposure Time.Clinical orthopaedics and related research · 2016Article
- Antimicrobial Release From Prefabricated Spacers Is Variable and the Dose Is Low.Clinical orthopaedics and related research · 2015Article
- Local gentamicin delivery from resorbable viscous hydrogels is therapeutically effective.Clinical orthopaedics and related research · 2015Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTissue distribution after local delivery has been quantified over a period of 5 hours on 7-T MRI in a rabbit model using gadolinium-labeled diethylenetriamine pentaacetic acid (Gd-DTPA) as an antimicrobial surrogate; however, it is unknown how the Gd-DTPA load in a local depot will affect the duration of high-concentration Gd-DTPA in local tissues after surgical débridement. QUESTIONS/PURPOSES: We determined whether the Gd-DTPA load in bone cement affected its local tissue distribution over a period of 1 month after local delivery.
methodsA 1-cm3 soft tissue dead space was created in the quadriceps of seven rabbits and filled with gadolinium-loaded bone cement. At 7, 14, and 33 days, the volume of tissue with a Gd-DTPA concentration of more than 14 μg/mL was calculated from T1-weighted images using 7-T MRI. Differences in volumes of distribution were analyzed with ANOVA.
resultsThe volume of tissue with more than 14 μg/mL Gd-DTPA was much larger from higher gadolinium loads on Day 7 (p=0.02) (2121 mm3 for 10 g and 665 mm3 for 1 g) and smaller with time for the 10-g formulation (2121 mm3 on Day 7 and 1241 mm3 on Day 14).
conclusionsVolume of distribution and duration of Gd-DTPA after local delivery increased with increasing load in the cement and decreased with time. CLINICAL RELEVANCE: For local delivery, high antimicrobial concentrations would be expected in greater volumes of tissue, for longer durations, when higher antimicrobial loads are used.
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