ArticleInternational orthopaedics2014
Supercharging irradiated allografts with mesenchymal stem cells improves acetabular bone grafting in revision arthroplasty.
Article in International orthopaedics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 54 citations in OpenAlex.
- MiR-22-3p facilitates bone marrow mesenchymal stem cell osteogenesis and fracture healing through the SOSTDC1-PI3K/AKT pathway.International journal of experimental pathology · 2024Article
- Revolutionizing bone defect healing: the power of mesenchymal stem cells as seeds.Frontiers in bioengineering and biotechnology · 2024Review
- Mummies are alive within International Orthopaedics: Ramses II speaks with SICOT surgeons about orthopaedics in ancient Egypt and today.International orthopaedics · 2023Article
- Bone Healing Materials in the Treatment of Recalcitrant Nonunions and Bone Defects.International journal of molecular sciences · 2022Review
- Targeting regulation of stem cell exosomes: Exploring novel strategies for aseptic loosening of joint prosthesis.Frontiers in bioengineering and biotechnology · 2022Review
- Frontiers in non-union research.EFORT open reviews · 2020Review
- Intravenous administration of multipotent stromal cells and bone allograft modification to enhance allograft healing.Regenerative medicine · 2019Article
- Single-stage treatment of infected tibial non-unions and osteomyelitis with bone marrow granulocytes precursors protecting bone graft.International orthopaedics · 2018Article
- [Therapeutic utilization of stem cells in orthopedics].Der Orthopade · 2017Article
- Mesenchymal stem cells in the aseptic loosening of total joint replacements.Journal of biomedical materials research. Part A · 2017Review
- Allografts supercharged with bone-marrow-derived mesenchymal stem cells possess equivalent osteogenic capacity to that of autograft: a study with long-term follow-ups of human biopsies.International orthopaedics · 2017Article
- Bone grafts, bone graft extenders, substitutes and enhancers for acetabular reconstruction in revision total hip arthroplasty.EFORT open reviews · 2016Review
- The immunosuppressive capacity of human mesenchymal stromal cells derived from amnion and bone marrow.Biochemistry and biophysics reports · 2016Article
- Bone Marrow Stromal Stem Cells in Tissue Engineering and Regenerative Medicine.Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme · 2016Review
- Ceramic-on-ceramic THA associated with fewer dislocations and less muscle degeneration by preserving muscle progenitors.Clinical orthopaedics and related research · 2015Article
- The use of customized cages in revision total hip arthroplasty for Paprosky type III acetabular bone defects.International orthopaedics · 2015Article
- Use of bone marrow derived stem cells in trauma and orthopaedics: A review of current concepts.World journal of orthopedics · 2015Review
- Biological aspects of segmental bone defects management.International orthopaedics · 2015Review
- Bone transplantation and tissue engineering, part III: allografts, bone grafting and bone banking in the twentieth century.International orthopaedics · 2015Article
- Acetabular revision arthroplasty using trabecular titanium implants.International orthopaedics · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe procedure of bone allografting associated with a reinforcement device is widely used for acetabulum revision. However in absence of biologic fixation of the allograft, failure of the reconstruction may occur. We made the hypothesis that it would be possible to load these grafts with bone marrow derived mesenchymal stem cells (MSC) to rescue the osteogenic capacity of an allogenic dead bone and therefore enhance incorporation of allografts with the host bone and decrease the number of failures related to the allograft.
methodWe identified 60 patients who had undergone acetabular component revision for aseptic failure of cemented implants associated with massive periacetabular osteolysis and Paprosky type 3A or 3B classification (without pelvic discontinuity) between 1996 and 2001. The study group of 30 patients received MSCs in the allograft and at the host graft junction. The average total number of MSCs received by each patient was 195,000 cells (range 86,000-254,000 cells). The control group of 30 patients had no MSCs in the allograft. Patients were matched for the size of periacetabular osteolysis (Paprosky type 3A or 3B). We compared the evolution of the allografts and evaluated cup migration and revision of the hips as end points at a minimum of 12 years or until failure.
resultBetter radiographic graft union rates and less allograft resorption were observed with allografts loaded with stem cells. Allograft resorption was significantly decreased in the group with allograft loaded with MSCs (1.2 cm(2) -range 0-2.3 cm(2)-of resorption on radiographs in the group with MSCs; versus 6 cm(2), range 2.1-8.5 cm(2) in the group without MSCs). The rate of mechanical failure was highest (p = 0.01) among the 30 patients with allograft without stem cells (9/30; 30 %) compared with no failures for patients with allograft loaded with stem cells. Revision of the cup was necessary in nine patients in the control group. No revision was performed in the 30 patients of the study group with MSCs.
conclusionFor acetabular defect reconstruction, loading the allograft with MSCs has resulted in a lower rate of failure as compared with allograft without MSCs.
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