ArticleApplied and environmental microbiology2014
Interspecific quorum sensing mediates the resuscitation of viable but nonculturable vibrios.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 1 of them a synthesis that pooled it.
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Who cites it
47 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Distribution of Fatal Vibrio Vulnificus Necrotizing Skin and Soft-Tissue Infections: A Systematic Review and Meta-Analysis.Medicine · 2016Pooled it
- Effects of Nutritional Conditions and Exogenous N-Acyl-Homoserine Lactones on the Resuscitation of Sodium Hypochlorite-Induced DormantMicroorganisms · 2026Article
- Mechanism insights into the regulation of the LuxS/AI-2 quorum sensing system on the formation of viable but nonculturable state in biofilm cells of beer-spoilage Lactiplantibacillus plantarum.Journal of advanced research · 2026Article
- How Salmonella Works Under Osmotic and Desiccation Stresses.Comprehensive reviews in food science and food safety · 2026Review
- D-amino acids inhibit biofilm formation in Escherichia coli and increase antibiotic susceptibility in multidrug-resistant bacteria.Folia microbiologica · 2026Article
- Differential Induction and Resuscitation of the Viable but Non-Culturable (VBNC) State inMicroorganisms · 2026Article
- The sleeping bacterium: shedding light on the resuscitation mechanism.European biophysics journal : EBJ · 2026Article
- Repeat Prolonged Chlorination at Low Dose Induces Chlorine Tolerance inEnvironment & health (Washington, D.C.) · 2026Article
- Article
- DPO production by gut commensals suggests a broader role in bacterial communication and host-microbiome interactions.NPJ biofilms and microbiomes · 2025Article
- Exploring the effects of phenolic compounds and essential oils in poultry: A sustainable strategy to combat Salmonella biofilm infections.Poultry science · 2025Review
- Probiotic Viability Reconsidered: Integrating VBNC Resuscitation and Culture-Independent Methods for Accurate Probiotic Enumeration.Microorganisms · 2025Review
- Article
- Viable but non-cultivable state in oral microbiota: a critical review of an underexplored microbial survival strategy.Frontiers in cellular and infection microbiology · 2025Review
- Intracellular ATP concentration is a key regulator of bacterial cell fate.Journal of bacteriology · 2024Article
- Quorum regulated latent environmental cells of toxigenic Vibrio cholerae and their role in cholera outbreaks.Gut pathogens · 2024Review
- Resuscitation of viable but nonculturable bacteria promoted by ATP-mediated NADJournal of advanced research · 2024Article
- Wake Up! Resuscitation of Viable but Nonculturable Bacteria: Mechanism and Potential Application.Foods (Basel, Switzerland) · 2022Review
- Overview of VBNC, a survival strategy for microorganisms.3 Biotech · 2022Review
- A novel finding of intra-genus inhibition of quorum sensing in Vibrio bacteria.Scientific reports · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Entry and exit from dormancy are essential survival mechanisms utilized by microorganisms to cope with harsh environments. Many bacteria, including the opportunistic human pathogen Vibrio vulnificus, enter a form of dormancy known as the viable but nonculturable (VBNC) state. VBNC cells can resuscitate when suitable conditions arise, yet the molecular mechanisms facilitating resuscitation in most bacteria are not well understood. We discovered that bacterial cell-free supernatants (CFS) can awaken preexisting dormant vibrio populations within oysters and seawater, while CFS from a quorum sensing mutant was unable to produce the same resuscitative effect. Furthermore, the quorum sensing autoinducer AI-2 could induce resuscitation of VBNC V. vulnificus in vitro, and VBNC cells of a mutant unable to produce AI-2 were unable to resuscitate unless the cultures were supplemented with exogenous AI-2. The quorum sensing inhibitor cinnamaldehyde delayed the resuscitation of wild-type VBNC cells, confirming the importance of quorum sensing in resuscitation. By monitoring AI-2 production by VBNC cultures over time, we found quorum sensing signaling to be critical for the natural resuscitation process. This study provides new insights into the molecular mechanisms stimulating VBNC cell exit from dormancy, which has significant implications for microbial ecology and public health.
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