ArticleScientific reports2014
A common fungal volatile organic compound induces a nitric oxide mediated inflammatory response in Drosophila melanogaster.
Article in Scientific reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- The underexplored mycobiome: insights from Drosophila into human health and disease.Antonie van Leeuwenhoek · 2026Review
- Classification, biology and entomopathogenic fungi-based management and their mode of action againstFrontiers in microbiology · 2024Review
- Anti-Insect Properties ofMicroorganisms · 2023Review
- Mutational Analysis ofJournal of fungi (Basel, Switzerland) · 2023Article
- Modulation of the NO-cGMP pathway has no effect on olfactory responses in theFrontiers in cellular neuroscience · 2023Article
- Discovery, total syntheses and potent anti-inflammatory activity of pyrrolinone-fused benzoazepine alkaloids Asperazepanones A and B from Aspergillus candidus.Communications chemistry · 2022Article
- In Vitro Systems for Toxicity Evaluation of Microbial Volatile Organic Compounds on Humans: Current Status and Trends.Journal of fungi (Basel, Switzerland) · 2022Review
- Genomic Analyses ofJournal of fungi (Basel, Switzerland) · 2021Article
- Article
- Insights on the Larvicidal Mechanism of Action of Fractions and Compounds from Aerial Parts ofMolecules (Basel, Switzerland) · 2020Article
- Volatile Organic Compounds Produced by Human Pathogenic Fungi Are Toxic toFrontiers in fungal biology · 2020Article
- The position paper of the Polish Society of Allergology on climate changes, natural disasters and allergy and asthma.Postepy dermatologii i alergologii · 2018Review
- Nitric Oxide Mediates Insect Cellular Immunity via Phospholipase A2 Activation.Journal of innate immunity · 2018Article
- Review
- Air Pollution and Climate Change Effects on Allergies in the Anthropocene: Abundance, Interaction, and Modification of Allergens and Adjuvants.Environmental science & technology · 2017Article
- Is Mold Toxicity Really a Problem for Our Patients? Part 2-Nonrespiratory Conditions.Integrative medicine (Encinitas, Calif.) · 2016Article
- Review
- Immune responses to airborne fungi and non-invasive airway diseases.Seminars in immunopathology · 2015Review
- Silver linings: a personal memoir about Hurricane Katrina and fungal volatiles.Frontiers in microbiology · 2015Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using a Drosophila model, we previously demonstrated truncated life span and neurotoxicity with exposure to 1-octen-3-ol, the volatile organic compound (VOC) responsible for much of the musty odor found in mold-contaminated indoor spaces. In this report, using biochemical and immunological assays, we show that exposure to 0.5 ppm 1-octen-3-ol induces a nitric oxide (NO) mediated inflammatory response in hemocytes, Drosophila innate immune cells. Moreover, exposed Drosophila brains show increased peroxynitrite expression. An increase in nitrite levels is observed with toluene and 1-octen-3-ol but not with 1-butanol. Pharmacological inhibitors of nitric oxide synthase (NOS) namely, L-NAME, D-NAME and minocycline, and NOS mutants show improvements of life span among 1-octen-3-ol exposed flies. Exposure to 1-octen-3-ol also induces NOS expression in larval tracheal tissues and remodels tracheal epithelial lining. These findings suggest a possible mechanistic basis for some of the reported adverse health effects attributed to mold exposure and demonstrates the utility of this in vivo Drosophila model to complement existing model systems for understanding the role of inflammation in VOC-mediated toxicity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.