Evidence map›Paper›PMID 24509894›Full record

Trial reportRheumatology international2014

Oxytocin nasal spray in fibromyalgic patients.

S Mameli, G M Pisanu, S Sardo, A Marchi, A Pili, M Carboni, L Minerba, G Trincas, M G Carta, M R Melis and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Rheumatology international, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05846087 (Mobile App-delivered Sleep Therapy), which is not on this map. Cited by 25 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 4 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05846087 nacompletednot on this mapstarted 2023, after this paper: background citation

Mobile App-delivered Sleep Therapy (SleepFix) for Individuals With Chronic Low Back Pain and Insomnia: a Randomized Controlled Trial With Internal Pilot Study

TypeinterventionalSponsorWoolcock Institute of Medical ResearchRan2023 to 2025Enrolled106ConditionsChronic Low-back Pain, InsomniaArmssleep retraining therapy, sleep health education modules
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 4 syntheses or guidelines pooled it, 54 citations in OpenAlex.

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  19. [Effect of oxytocin on human pain perception].Schmerz (Berlin, Germany) · 2016
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

S MameliPain Therapy Unit, "A. Businco" Hospital, ASL 8, Cagliari, Italy.
G M Pisanu
S Sardo
A Marchi
A Pili
M Carboni
L Minerba
G Trincas
M G Carta
M R Melis
R Agabio
University of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia is a pain disorder associated with frequent comorbid mood, anxiety, and sleep disorders. Despite the frequent use of a complex, poly-drug pharmacotherapy, treatment for fibromyalgia is of limited efficacy. Oxytocin has been reported to reduce the severity of pain, anxiety, and depression, and improve the quality of sleep, suggesting that it may be useful to treat fibromyalgia. To evaluate this hypothesis, 14 women affected by fibromyalgia and comorbid disorders, assuming a complex pharmacotherapy, were enrolled in a double-blind, crossover, randomized trial to receive oxytocin and placebo nasal spray daily for 3 weeks for each treatment. Order of treatment (placebo-oxytocin or oxytocin-placebo) was randomly assigned. Patients were visited once a week. At each visit, the following instruments were administered: an adverse drug reaction record card, Visual Analog Scale of Pain Intensity, Spielberger State Anxiety Inventory, Zung Self-rating Depression Scale, and SF-12. Women self-registered painkiller assumption, pain severity, and quality of sleep in a diary. Unlikely, oxytocin nasal spray (80 IU a day) did not induce positive therapeutic effects but resulted to be safe, devoid of toxicity, and easy to handle.

Indexed as

Administration, IntranasalAerosolsAnxietyComorbidityCross-Over StudiesDepressionDouble-Blind MethodFemaleFibromyalgiaHumansMiddle AgedMusculoskeletal PainOxytocinPain MeasurementPsychiatric Status Rating ScalesQuality of LifeAerosolsOxytocin

Identifiers

PMID24509894
OpenAlexW2126391111

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.