Evidence map›Paper›PMID 24509785›Full record

ReviewNature reviews. Microbiology2014

Biogenesis and functions of bacterial S-layers.

Robert P Fagan, Neil F Fairweather

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 217 papers.

0numbers the graph read from it
0cells of the map it votes in
217citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

217 citing papers in PubMed.

  1. Article
  2. Exploring the Adhesion Potential ofFoods (Basel, Switzerland) · 2026
    Article
  3. Review
  4. Collective fluctuations underlying nanobody inhibitory activity targetingbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Clostridioides difficile pathogenesis and control.Nature reviews. Microbiology · 2026
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Cytoplasmic membrane vesicles fromFrontiers in microbiology · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

157 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Robert P FaganDepartment of Molecular Biology and Biotechnology, University of Sheffield, S10 2TN, UK.
Neil F FairweatherDepartment of Life Sciences, MRC Centre for Molecular Bacteriology and Infection, Imperial College London, SW7 2AZ, UK.

Funding

Medical Research Council G0800170Medical Research Council G1001721Wellcome Trust 090969Z
6 · The paper itself

Abstract

The outer surface of many archaea and bacteria is coated with a proteinaceous surface layer (known as an S-layer), which is formed by the self-assembly of monomeric proteins into a regularly spaced, two-dimensional array. Bacteria possess dedicated pathways for the secretion and anchoring of the S-layer to the cell wall, and some Gram-positive species have large S-layer-associated gene families. S-layers have important roles in growth and survival, and their many functions include the maintenance of cell integrity, enzyme display and, in pathogens and commensals, interaction with the host and its immune system. In this Review, we discuss our current knowledge of S-layer and related proteins, including their structures, mechanisms of secretion and anchoring and their diverse functions.

Indexed as

AnimalsArchaeaBacteriaCell WallGenetic VariationHumansMembrane GlycoproteinsModels, BiologicalMultigene FamilyProtein Structure, TertiaryMembrane GlycoproteinsS-layer proteins

Identifiers

PMID24509785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.