ArticleHuman genetics2014
Characterization of the DYX2 locus on chromosome 6p22 with reading disability, language impairment, and IQ.
Article in Human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
21 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Opposite Associations between Individual KIAA0319 Polymorphisms and Developmental Dyslexia Risk across Populations: A Stratified Meta-Analysis by the Study Population.Scientific reports · 2016Pooled it
- Pooled it
- Targeted analysis of dyslexia-associated regions on chromosomes 6, 12 and 15 in large multigenerational cohorts.PloS one · 2025Article
- Phonological awareness mediates the relationship between DCDC2 and reading performance with home environment.NPJ science of learning · 2024Article
- Developmental dyslexia susceptibility genes DNAAF4, DCDC2, and NRSN1 are associated with brain function in fluently reading adolescents and young adults.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Orthographic Depth May Influence the Degree of Severity of Maze Learning Performance in Children at Risk for Reading Disorder.Developmental neuroscience · 2022Article
- Identification of Phonology-Related Genes and Functional Characterization of Broca's and Wernicke's Regions in Language and Learning Disorders.Frontiers in neuroscience · 2021Article
- Identifying Dyslexia: Link between Maze Learning and Dyslexia Susceptibility Gene, DCDC2, in Young Children.Developmental neuroscience · 2021Article
- Identifying interactive biological pathways associated with reading disability.Brain and behavior · 2020Article
- Neuroimaging genetics studies of specific reading disability and developmental language disorder: A review.Language and linguistics compass · 2019Article
- A molecular-genetic and imaging-genetic approach to specific comprehension difficulties in children.NPJ science of learning · 2018Article
- Neuropsychology of Learning Disabilities: The Past and the Future.Journal of the International Neuropsychological Society : JINS · 2017Review
- Study of Genetic Association WithClinical practice and epidemiology in mental health : CP & EMH · 2017Article
- [Research advances in susceptible genes for developmental dyslexia in children].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016Review
- A sequence variant associating with educational attainment also affects childhood cognition.Scientific reports · 2016Article
- Dyslexia and language impairment associated genetic markers influence cortical thickness and white matter in typically developing children.Brain imaging and behavior · 2016Article
- The regulatory element READ1 epistatically influences reading and language, with both deleterious and protective alleles.Journal of medical genetics · 2016Article
- A missense mutation in DCDC2 causes human recessive deafness DFNB66, likely by interfering with sensory hair cell and supporting cell cilia length regulation.Human molecular genetics · 2015Article
- The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.Genes, brain, and behavior · 2015Article
- DCDC2 polymorphism is associated with left temporoparietal gray and white matter structures during development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
Corrections and comments
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Authors and funding
14 authors at 9 institutions in 5 countries.
Funding
Abstract
Reading disability (RD) and language impairment (LI) are common neurodevelopmental disorders with moderately strong genetic components and lifelong implications. RD and LI are marked by unexpected difficulty acquiring and processing written and verbal language, respectively, despite adequate opportunity and instruction. RD and LI-and their associated deficits-are complex, multifactorial, and often comorbid. Genetic studies have repeatedly implicated the DYX2 locus, specifically the genes DCDC2 and KIAA0319, in RD, with recent studies suggesting they also influence LI, verbal language, and cognition. Here, we characterize the relationship of the DYX2 locus with RD, LI, and IQ. To accomplish this, we developed a marker panel densely covering the 1.4 Mb DYX2 locus and assessed association with reading, language, and IQ measures in subjects from the Avon Longitudinal Study of Parents and Children. We then replicated associations in three independent, disorder-selected cohorts. As expected, there were associations with known RD risk genes KIAA0319 and DCDC2. In addition, we implicated markers in or near other DYX2 genes, including TDP2, ACOT13, C6orf62, FAM65B, and CMAHP. However, the LD structure of the locus suggests that associations within TDP2, ACOT13, and C6orf62 are capturing a previously reported risk variant in KIAA0319. Our results further substantiate the candidacy of KIAA0319 and DCDC2 as major effector genes in DYX2, while proposing FAM65B and CMAHP as new DYX2 candidate genes. Association of DYX2 with multiple neurobehavioral traits suggests risk variants have functional consequences affecting multiple neurological processes. Future studies should dissect these functional, possibly interactive relationships of DYX2 candidate genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.