ArticleMicrobiology (Reading, England)2014
β-Phosphoglucomutase contributes to aciduricity in Streptococcus mutans.
Article in Microbiology (Reading, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 18 citations in OpenAlex.
- Review
- Studies of Streptococcus anginosus Virulence in Dictyostelium discoideum and Galleria mellonella Models.Infection and immunity · 2023Article
- The Route of Sucrose Utilization byFrontiers in microbiology · 2021Article
- Extracellular polysaccharide synthesis in a bloom-forming strain of Microcystis aeruginosa: implications for colonization and buoyancy.Scientific reports · 2019Article
- Searching whole genome sequences for biochemical identification features of emerging and reemerging pathogenic Corynebacterium species.Functional & integrative genomics · 2018Article
- [Role of SMU.2055 gene in regulating acid resistance of Streptococcus mutans UA159].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2018Article
- Transcriptome-wide survey of gene expression changes and alternative splicing in Trichophyton rubrum in response to undecanoic acid.Scientific reports · 2018Article
- RgpF Is Required for Maintenance of Stress Tolerance and Virulence in Streptococcus mutans.Journal of bacteriology · 2017Article
- Evaluation of Galleria mellonella larvae for studying the virulence of Streptococcus suis.BMC microbiology · 2016Article
- Galleria mellonella infection models for the study of bacterial diseases and for antimicrobial drug testing.Virulence · 2016Review
- PlsX deletion impacts fatty acid synthesis and acid adaptation in Streptococcus mutans.Microbiology (Reading, England) · 2016Article
- Loss of NADH Oxidase Activity in Streptococcus mutans Leads to Rex-Mediated Overcompensation in NAD+ Regeneration by Lactate Dehydrogenase.Journal of bacteriology · 2015Article
- Functional profiling in Streptococcus mutans: construction and examination of a genomic collection of gene deletion mutants.Molecular oral microbiology · 2015Article
- Regulation of fatty acid biosynthesis by the global regulator CcpA and the local regulator FabT in Streptococcus mutans.Molecular oral microbiology · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Streptococcus mutans encounters an array of sugar moieties within the oral cavity due to a varied human diet. One such sugar is β-d-glucose 1-phosphate (βDG1P), which must be converted to glucose 6-phosphate (G6P) before further metabolism to lactic acid. The conversion of βDG1P to G6P is mediated by β-phosphoglucomutase, which has not been previously observed in any oral streptococci, but has been extensively characterized and the gene designated pgmB in Lactococcus lactis. An orthologue was identified in S. mutans, SMU.1747c, and deletion of the gene resulted in the inability of the deletion strain to convert βDG1P to G6P, indicating that SMU.1747c is a β-phosphoglucomutase and should be designated pgmB. In this study, we sought to characterize how deletion of pgmB affected known virulence factors of S. mutans, specifically acid tolerance. The ΔpgmB strain showed a decreased ability to survive acid challenge. Additionally, the strain lacking β-phosphoglucomutase had a diminished glycolytic profile compared with the parental strain. Deletion of pgmB had a negative impact on the virulence of S. mutans in the Galleria mellonella (greater wax worm) animal model. Our results indicate that pgmB plays a role at the juncture of carbohydrate metabolism and virulence.
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