ReviewCurrent opinion in microbiology2014
Cyclic-AMP and bacterial cyclic-AMP receptor proteins revisited: adaptation for different ecological niches.
Review in Current opinion in microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 118 citations in OpenAlex.
- ISmLife · 2026Article
- In Salmonella Typhimurium, YiiD Modulates cAMP Levels in Lag Phase During Growth on Succinate.Molecular microbiology · 2026Article
- Global Control of Phosphotransferase System-Mediated Carbon Metabolism by CRP Is Associated with Metabolic Homeostasis and Virulence inMicroorganisms · 2026Article
- Cell-free genomics reveals fundamental regulatory principles of the Mycobacterium tuberculosis transcription cycle.Molecular cell · 2026Article
- A bacterial NO-binding sensor domain evolved through acquisition of a cytochrome-derived c-type heme-binding motif.bioRxiv : the preprint server for biology · 2026Article
- Molecular Basis of Persister Awakening and Lag-Phase Recovery inInternational journal of molecular sciences · 2026Review
- Article
- Inactivation of cAMP receptor protein (MSMEG_6189) increases isoniazid susceptibility inJournal of bacteriology · 2025Article
- Sucrose reduces biofilm formation byBiofilm · 2025Article
- Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements.Nucleic acids research · 2025Article
- Article
- Exploring the diversity of anti-defense systems across prokaryotes, phages, and mobile genetic elements.bioRxiv : the preprint server for biology · 2024Article
- Structural and functional characterization of cyclic pyrimidine-regulated anti-phage system.Nature communications · 2024Article
- Review
- The cAMP Receptor Protein (CRP) ofAnimals : an open access journal from MDPI · 2024Article
- cAMP competitively inhibits periplasmic phosphatases to coordinate nutritional growth with competence of Haemophilus influenzae.The Journal of biological chemistry · 2023Article
- Laboratory evolution, transcriptomics, and modeling reveal mechanisms of paraquat tolerance.Cell reports · 2023Article
- The symbolic power of nucleotide second messengers - or how prokaryotes link sensing and responding to their outside world.microLife · 2023Article
- Structural and functional diversity of bacterial cyclic nucleotide perception by CRP proteins.microLife · 2023Review
- Putative nucleotide-based second messengers in archaea.microLife · 2023Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Escherichia coli cyclic-AMP receptor protein (CRP) represents one of the paradigms of bacterial gene regulation. Yet despite decades of intensive study, new information continues to emerge that prompts reassessment of this classic regulatory system. Moreover, in recent years CRPs from several other bacterial species have been characterized, allowing the general applicability of the CRP paradigm to be tested. Here the properties of the E. coli, Mycobacterium tuberculosis and Pseudomonas putida CRPs are considered in the context of the ecological niches occupied by these bacteria. It appears that the cyclic-AMP-CRP regulatory system has been adapted to respond to distinct external and internal inputs across a broad sensitivity range that is, at least in part, determined by bacterial lifestyles.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.