ArticleNature neuroscience2014
The endocannabinoid system controls food intake via olfactory processes.
Article in Nature neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 2 of them syntheses that pooled it.
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Who cites it
124 citing papers in PubMed, 2 syntheses or guidelines pooled it, 273 citations in OpenAlex.
- Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review.International journal of obesity (2005) · 2024Pooled it
- GWAS and eQTL analysis identifies a SNP associated with both residual feed intake and GFRA2 expression in beef cattle.Scientific reports · 2018Pooled it
- The role of insulin sensitivity and intranasally applied insulin on olfactory perception.Scientific reports · 2019Trial
- Trial
- Effects of 20 mg oral Δ(9) -tetrahydrocannabinol on the olfactory function of healthy volunteers.British journal of clinical pharmacology · 2014Trial
- Insulin receptor signaling in gustatory cells suppresses sugar taste sensitivity and feeding iniScience · 2026Article
- Target-dependent routing of sensory information in the olfactory system.Communications biology · 2026Article
- Multiple Roles of Cannabinoids in the Olfactory System.Brain sciences · 2026Review
- Genetic Tools in Rodents to Study Cannabinoid Functions.Current topics in behavioral neurosciences · 2026Review
- Deletion of NPAS4 in olfactory bulb principal neurons alters E/I balance and impairs decoding of chemically similar odour molecules.The Journal of physiology · 2026Article
- Cannabis produces acute hyperphagia in humans and rodents via increased reward valuation for, and motivation to, acquire food.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The Endocannabinoid System in the Development and Treatment of Obesity: Searching for New Ideas.International journal of molecular sciences · 2025Review
- Essential Role of the Anterior Piriform Cortex in Mediating Social Novelty Output via a Top-Down Circuit.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cannabidiol enhances socially transmitted food preference: a role of acetylcholine in the mouse basal forebrain.Psychopharmacology · 2025Article
- [Application of optogenetic technology in the research on olfactory bulb neural projection from advanced brain regions to regulate olfactory signal processing].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2024Review
- Article
- Beyond the Scale: Exploring the Endocannabinoid System's Impact on Obesity.Current diabetes reports · 2024Review
- Olfactory bulb tracks breathing rhythms and place in freely behaving mice.bioRxiv : the preprint server for biology · 2024Article
- Cannabinoid regulation of sex-dependent murine odorant-stimulated salivation.Scientific reports · 2024Article
- Anterior Olfactory Cortices Differentially Transform Bottom-Up Odor Signals to Produce Inverse Top-Down Outputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
64 more citing papers are in PubMed but not listed here.
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Authors and funding
27 authors at 15 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hunger arouses sensory perception, eventually leading to an increase in food intake, but the underlying mechanisms remain poorly understood. We found that cannabinoid type-1 (CB1) receptors promote food intake in fasted mice by increasing odor detection. CB1 receptors were abundantly expressed on axon terminals of centrifugal cortical glutamatergic neurons that project to inhibitory granule cells of the main olfactory bulb (MOB). Local pharmacological and genetic manipulations revealed that endocannabinoids and exogenous cannabinoids increased odor detection and food intake in fasted mice by decreasing excitatory drive from olfactory cortex areas to the MOB. Consistently, cannabinoid agonists dampened in vivo optogenetically stimulated excitatory transmission in the same circuit. Our data indicate that cortical feedback projections to the MOB crucially regulate food intake via CB1 receptor signaling, linking the feeling of hunger to stronger odor processing. Thus, CB1 receptor-dependent control of cortical feedback projections in olfactory circuits couples internal states to perception and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.