ArticleAnnals of surgery2014
Total pancreatectomy and islet autotransplantation in children for chronic pancreatitis: indication, surgical techniques, postoperative management, and long-term outcomes.
Article in Annals of surgery, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.
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Who cites it
70 citing papers in PubMed, 1 synthesis or guideline pooled it, 196 citations in OpenAlex.
- Systematic review of early surgery for chronic pancreatitis: impact on pain, pancreatic function, and re-intervention.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2014Pooled it
- Total Pancreatectomy With Islet Autotransplantation Resolves Pain in Young Children With Severe Chronic Pancreatitis.Journal of pediatric gastroenterology and nutrition · 2017Trial
- Understanding the Pathophysiology of Chronic Pancreatitis: A Comprehensive Review Unraveling Pain Mechanisms and the Role of Psychosocial Factors.Journal of clinical medicine · 2026Review
- Total pancreatectomy with islet auto-transplantation in pediatric patients results in significantly decreased opioid use, improved long-term pain and quality of life outcomes.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2025Article
- Predictors of Diabetes Outcomes at 1 Year After Islet Autotransplantation: Data From a Multicenter Cohort Study.Diabetes care · 2025Observational
- Longitudinal Quality of Life and Glycemic Outcomes of Total Pancreatectomy With Islet Autotransplantation in Children With Chronic Pancreatitis Followed in a Pediatric Multidisciplinary Pancreas Clinic.Pediatric transplantation · 2024Article
- Challenges of Managing Type 3c Diabetes in the Context of Pancreatic Resection, Cancer and Trauma.Journal of clinical medicine · 2024Review
- Current status of total pancreatectomy with islet autotransplantation for chronic and recurrent acute pancreatitis.Annals of gastroenterological surgery · 2024Review
- Addressing long-term mortality risk in patients undergoing total pancreatectomy with islet autotransplant (TPIAT): causes of death and risk factors.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2024Article
- Quality of life after pancreatic surgery.World journal of gastroenterology · 2024Review
- Islet graft function by mixed meal tolerance testing is sustained over 4 years in young children undergoing total pancreatectomy with islet autotransplantation.Clinical transplantation · 2023Article
- Nutritional Risks in Patients Undergoing Total Pancreatectomy Islet AutoTransplantation in the POST Consortium.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Observational
- Metabolic Outcomes in Pediatric Patients One-Year Post-Total Pancreatectomy with Islet Autotransplantation after Early Pump Initiation.Journal of clinical medicine · 2023Article
- Outcomes of total pancreatectomy with islet autotransplantation: A systematic review and meta-analysis.World journal of transplantation · 2023Article
- Observational
- Acute Pancreatitis: Diagnosis and Treatment.Drugs · 2022Review
- Predictors of Glycemic Outcomes at 1 Year Following Pediatric Total Pancreatectomy With Islet Autotransplantation.Diabetes care · 2022Article
- Hereditary pancreatitis: An updated review in pediatrics.World journal of clinical pediatrics · 2022Review
- Assessment of exocrine pancreatic function in children and adolescents with direct and indirect testing.Frontiers in pediatrics · 2022Review
- Surgical approach and short-term outcomes in adults and children undergoing total pancreatectomy with islet autotransplantation: A report from the Prospective Observational Study of TPIAT.Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] · 2022Observational
10 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
16 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveDescribe the surgical technique, complications, and long-term outcomes of total pancreatectomy and islet autotransplantation (TP-IAT) in a large series of pediatric patients.
backgroundSurgical management of childhood pancreatitis is not clear; partial resection or drainage procedures often provide transient pain relief, but long-term recurrence is common due to the diffuse involvement of the pancreas. Total pancreatectomy (TP) removes the source of the pain, whereas islet autotransplantation (IAT) potentially can prevent or minimize TP-related diabetes.
methodsRetrospective review of 75 children undergoing TP-IAT for chronic pancreatitis who had failed medical, endoscopic, or surgical treatment between 1989 and 2012.
resultsPancreatitis pain and the severity of pain statistically improved in 90% of patients after TP-IAT (P < 0.001). The relief from narcotics was sustained. Of the 75 patients undergoing TP-IAT, 31 (41.3%) achieved insulin independence. Younger age (P = 0.032), lack of prior Puestow procedure (P = 0.018), lower body surface area (P = 0.048), higher islet equivalents (IEQ) per kilogram body weight (P = 0.001), and total IEQ (100,000) (P = 0.004) were associated with insulin independence. By multivariate analysis, 3 factors were associated with insulin independence after TP-IAT: (1) male sex, (2) lower body surface area, and (3) higher total IEQ per kilogram body weight. Total IEQ (100,000) was the single factor most strongly associated with insulin independence (odds ratio = 2.62; P < 0.001).
conclusionsTotal pancreatectomy and islet autotransplantation provides sustained pain relief and improved quality of life. The β-cell function is dependent on islet yield. Total pancreatectomy and islet autotransplantation is an effective therapy for children with painful pancreatitis that failed medical and/or endoscopic management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.