ArticleJournal of clinical pathology1988
Antisera against epitopes resistant to denaturation on T3 (CD3) antigen can detect reactive and neoplastic T cells in paraffin embedded tissue biopsy specimens.
Article in Journal of clinical pathology, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 51 citations in OpenAlex.
- Growth pattern and distribution of follicular dendritic cells in mantle cell lymphoma: a clinicopathological study of 96 patients.Virchows Archiv : an international journal of pathology · 2006Article
- Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions.The American journal of pathology · 1999Article
- Childhood B cell lymphomas arising in the mediastinum.Journal of clinical pathology · 1993Article
- Twelve cases of Ki-1 positive anaplastic large cell lymphoma of skin.Journal of clinical pathology · 1991Article
- Antibody L26 recognizes an intracellular epitope on the B-cell-associated CD20 antigen.The American journal of pathology · 1990Article
- Detection of T cells in paraffin wax embedded tissue using antibodies against a peptide sequence from the CD3 antigen.Journal of clinical pathology · 1989Article
- Molecule detected in formalin fixed tissue by antibodies MT1, DF-T1, and L60 (Leu-22) corresponds to CD43 antigen.Journal of clinical pathology · 1989Article
- Immunohistochemical analysis of the retrobulbar tissues in Graves' ophthalmopathy.Clinical and experimental immunology · 1989Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Polyclonal rat antisera, raised against affinity purified CD3 antigen, gave strong immunoenzymatic labelling of T cells in routine paraffin embedded sections, with negligible background staining. The specificity of these reactions was confirmed by staining biopsy specimens from 21 previously phenotyped non-Hodgkin's lymphomas (including 14 of T cell origin and six of B cell origin). It is suggested that the ability of the polyclonal anti-CD3 antisera to detect T cells in paraffin sections is due to the presence in these sera of antibodies against fixation resistant epitopes on CD3 antigen, and that immunisation with purified denatured preparations of other white cell associated antigens may broaden the range of antibodies suitable for the phenotypic analysis of leucocytes in routine histological samples.
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