Trial reportNeuroImage2014
Re-wiring the brain: increased functional connectivity within primary somatosensory cortex following synchronous co-activation.
Trial report in NeuroImage, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- Evidence for frequency-dependent cortical plasticity in the human brain.Proceedings of the National Academy of Sciences of the United States of America · 2017Trial
- Brain structural connectivity increases concurrent with functional improvement: evidence from diffusion tensor MRI in children with cerebral palsy during therapy.NeuroImage. Clinical · 2015Trial
- Cortical Neurotransmitters Measured by Magnetic Resonance Spectroscopy Change Following Traumatic Brachial Plexus Injury.Journal of brachial plexus and peripheral nerve injury · 2025Article
- Artificial embodiment displaces cortical neuromagnetic somatosensory responses.Scientific reports · 2024Article
- Decoupling of interacting neuronal populations by time-shifted stimulation through spike-timing-dependent plasticity.PLoS computational biology · 2023Article
- A hybrid biological neural network model for solving problems in cognitive planning.Scientific reports · 2022Article
- GABA Modulates Frequency-Dependent Plasticity in Humans.iScience · 2020Article
- Positive and Negative Somatotopic BOLD Responses in Contralateral Versus Ipsilateral Penfield Homunculus.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Regionally Specific Regulation of Sensorimotor Network Connectivity Following Tactile Improvement.Neural plasticity · 2017Article
- Article
- Investigating the Stability of Fine-Grain Digit Somatotopy in Individual Human Participants.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Article
- Recovery of olfactory function induces neuroplasticity effects in patients with smell loss.Neural plasticity · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
The primary somatosensory cortex shows precise topographical organisation, but can be quickly modified by alterations to sensory inputs. Temporally correlated sensory inputs to the digits can result in the merging of digit representations on the cortical surface. Underlying mechanisms driving these changes are unclear but the strengthening of intra-cortical synaptic connections via Hebbian mechanisms has been suggested. We use fMRI measures of temporal coherence to infer alterations in the relative strength of neuronal connections between digit regions 2 and 4 following 3 hours of synchronous and asynchronous co-activation. Following synchronous co-activation we find a 20% increase in temporal coherence of the fMRI signal (p=0.0004). No significant change is seen following asynchronous co-activation suggesting that temporal coincidence between the two digit inputs during co-activation is driving this coherence change. In line with previous work we also find a trend towards reduced separation of the digit representations following synchronous co-activation and significantly increased separation for the asynchronous case. Increased coherence is significantly correlated with reduced digit separation for the synchronous case. This study shows that passive synchronous stimulation to the digits strengthens the underlying cortical connections between the digit regions in only a few hours, and that this mechanism may be related to topographical re-organisation.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.