Evidence map›Paper›PMID 24508601›Full record

ReviewCurrent opinion in structural biology2014

Progress in structural studies of telomerase.

Edward J Miracco, Jiansen Jiang, Darian D Cash, Juli Feigon

Abstract readReview

In one paragraph

Review in Current opinion in structural biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it

0cells of the map it votes in

9citing papers in PubMed

1.7field-weighted citation impact, top 16% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

Telomeres and telomerase in Sarcoma disease and therapy.International journal of medical sciences · 2024
Review
Prenatal stress modulates HPA axis homeostasis of offspring through dentate TERT independently of glucocorticoids receptor.Molecular psychiatry · 2023
Article
Structural Biology of Telomerase.Cold Spring Harbor perspectives in biology · 2019
Review
Structure and function of the N-terminal domain of the yeast telomerase reverse transcriptase.Nucleic acids research · 2018
Article
Progress in Human and Tetrahymena Telomerase Structure Determination.Annual review of biophysics · 2017
Review
Single-Molecule Studies of Telomeres and Telomerase.Annual review of biophysics · 2017
Review
New prospects for targeting telomerase beyond the telomere.Nature reviews. Cancer · 2016
Review
DGCR8 Acts as an Adaptor for the Exosome Complex to Degrade Double-Stranded Structured RNAs.Molecular cell · 2015
Article
Conjoined use of EM and NMR in RNA structure refinement.PloS one · 2015
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Edward J MiraccoDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.

Jiansen JiangDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Microbiology, Immunology and Molecular Genetics, University of California Los Angeles, Los Angeles, CA 90095, USA; California Nanosystems Institute, University of California Los Angeles, Los Angeles, CA 90095, USA.

Darian D CashDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA.

Juli FeigonDepartment of Chemistry and Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA; California Nanosystems Institute, University of California Los Angeles, Los Angeles, CA 90095, USA. Electronic address: feigon@mbi.ucla.edu.

University of California, Los Angeles · USCalifornia NanoSystems Institute · US

Funding

UCLA NIGMS T32 Program AssessmentT32GM007185 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI TORRES, JORGE · 1985 to 2020

$21.7M

STRUCTURE OF TELOMERIC DNA OLIGONUCLEOTIDESR01GM048123 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FEIGON, JULI · 1992 to 2018

$6.4M

Structural Studies of Telomerase HoloenzymeF32GM101874 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIRACCO, EDWARD JOHN · 2012 to 2013

$99k

NIGMS NIH HHS F32 GM101874NIGMS NIH HHS GM101874NIGMS NIH HHS GM48123NIGMS NIH HHS R01 GM048123NIGMS NIH HHS T32 GM007185

6 · The paper itself

Abstract

Telomerase is the ribonucleoprotein (RNP) reverse transcriptase responsible for synthesizing the 3' ends of linear chromosomes. It plays critical roles in tumorigenesis, cellular aging, and stem cell renewal. The past two years have seen exciting progress in determining telomerase holoenzyme architecture and the structural basis of telomerase activity. Notably, the first electron microscopy structures of telomerase were reported, of the Tetrahymena thermophila telomerase holoenzyme and a human telomerase dimer. In addition to new structures of TERT and TER domains, the first structures of telomerase protein domains beyond TERT, and their complexes with TER or telomeric single-stranded DNA, were reported. Together these studies provide the first glimpse into the organization of the proteins and RNA in the telomerase RNP.

Indexed as

AnimalsHumansModels, MolecularProtein MultimerizationTelomeraseTetrahymena thermophilaTelomerase

Identifiers

PMID24508601

DOI10.1016/j.sbi.2014.01.008

PMCPMC3984607

OpenAlexW2024181718

What OpenQuestion holds

Textmetadata

LicenceTDM

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.