Evidence map›Paper›PMID 24508599›Full record

ReviewGastroenterology2014

Kingdom-agnostic metagenomics and the importance of complete characterization of enteric microbial communities.

Jason M Norman, Scott A Handley, Herbert W Virgin

Abstract readReview
In one paragraph

Review in Gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed.

  1. Beyond the gut microbe: Rethinking infection, microbiome harmony, and the one-health continuum.World journal of gastrointestinal pharmacology and therapeutics · 2026
    Review
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  18. Human gut microbiome: A primer for the clinician.JGH open : an open access journal of gastroenterology and hepatology · 2023
    Review
  19. Article
  20. Article

40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jason M NormanDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri.
Scott A HandleyDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri.
Herbert W VirginDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri. Electronic address: virgin@wustl.edu.

Funding

TRAINING PROGRAM IN IMMUNOLOGY AND IMMUNOGENETICST32AI007163 · NIAID · WASHINGTON UNIVERSITY · PI Kenneth M Murphy, Kodi S Ravichandran · 1985 to 2026
$14.8M
METAGENOMICS OF ENTERIC DISEASE IN SIV-INFECTED AND UNINFECTED MACAQUESR01OD011170 · OD · WASHINGTON UNIVERSITY · PI BAROUCH, DAN H., VIRGIN, HERBERT W · 2012 to 2014
$2.3M
SUSCEPTIBILILTY GENE-VIRUS INTERACTIONS IN INFLAMMATORY BOWEL DISEASER01AI084887 · NIAID · WASHINGTON UNIVERSITY · PI STAPPENBECK, THADDEUS S, VIRGIN, HERBERT W · 2010 to 2014
$1.9M
NIAID NIH HHS 5T32AI007163-35NIAID NIH HHS R01 AI084887NIAID NIH HHS T32 AI007163NIH HHS R01 OD011170
6 · The paper itself

Abstract

Advanced sequencing techniques have shown that bacteria are not the only complex and important microbes in the human intestine. Nonbacterial organisms, particularly the virome and the mycobiome, are important regulators of intestinal immunity and inflammation. The virome is mucosal and systemic; it can alter the host response to bacteria and interact with host genes and bacteria to contribute to disease pathogenesis. The human mycobiome is also complex and can contribute to intestinal inflammation. We review what has recently been learned about the nonbacterial and nonarchaeal microbes in the gastrointestinal tract, discussing their potential effects on health and disease and analytical approaches for their study. Studies of associations between the microbiome and intestinal pathology should incorporate kingdom-agnostic approaches if we are to fully understand intestinal health and disease.

Indexed as

MetagenomeMetagenomicsMicrobiotaAnimalsDisease SusceptibilityFungiGastrointestinal DiseasesGene Expression Regulation, FungalGene Expression Regulation, ViralHumansIntestinesVirusesMetagenomicsMycobiomeVirome

Identifiers

PMID24508599
PMCPMC4009354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.