ArticleHearing research2014
Auditory responses to electric and infrared neural stimulation of the rat cochlear nucleus.
Article in Hearing research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 56 citations in OpenAlex.
- Toward elucidating the mechanism of cochlear stimulation by infrared light.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Infrared light stimulates the cochlea through a mechanical displacement detected and amplified by hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Review
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Comparison of Responses to DCN vs. VCN Stimulation in a Mouse Model of the Auditory Brainstem Implant (ABI).Journal of the Association for Research in Otolaryngology : JARO · 2022Article
- Optoacoustically induced auditory brainstem responses in the mouse model enhanced through an absorbing film.Journal of biomedical optics · 2021Article
- Current Review of Optical Neural Interfaces for Clinical Applications.Micromachines · 2021Review
- Viral-mediated transduction of auditory neurons with opsins for optical and hybrid activation.Scientific reports · 2021Article
- μLED-based optical cochlear implants for spectrally selective activation of the auditory nerve.EMBO molecular medicine · 2020Article
- Auditory cortical activity elicited by infrared laser irradiation from the outer ear in Mongolian gerbils.PloS one · 2020Article
- Toward the Optical Cochlear Implant.Cold Spring Harbor perspectives in medicine · 2019Review
- First biocompatibility margins for optical stimulation at the eardrum via 532-nm laser pulses in a mouse model.Journal of biomedical optics · 2019Article
- Inhibitory effect of 980-nm laser on neural activity of the rat's cochlear nucleus.Neurophotonics · 2019Article
- Auditory brainstem stimulation with a conformable microfabricated array elicits responses with tonotopically organized components.Hearing research · 2019Article
- Ancestral Adeno-Associated Virus Vector Delivery of Opsins to Spiral Ganglion Neurons: Implications for Optogenetic Cochlear Implants.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Article
- Auditory Neural Activity in Congenitally Deaf Mice Induced by Infrared Neural Stimulation.Scientific reports · 2018Article
- Ryanodine and IPNeurophotonics · 2017Article
- A contrastive analysis of laser heating between the human and guinea pig cochlea by numerical simulations.Biomedical engineering online · 2016Article
- On the Horizon: Cochlear Implant Technology.Otolaryngologic clinics of North America · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
In an effort to improve the auditory brainstem implant, a prosthesis in which user outcomes are modest, we applied electric and infrared neural stimulation (INS) to the cochlear nucleus in a rat animal model. Electric stimulation evoked regions of neural activation in the inferior colliculus and short-latency, multipeaked auditory brainstem responses (ABRs). Pulsed INS, delivered to the surface of the cochlear nucleus via an optical fiber, evoked broad neural activation in the inferior colliculus. Strongest responses were recorded when the fiber was placed at lateral positions on the cochlear nucleus, close to the temporal bone. INS-evoked ABRs were multipeaked but longer in latency than those for electric stimulation; they resembled the responses to acoustic stimulation. After deafening, responses to electric stimulation persisted, whereas those to INS disappeared, consistent with a reported "optophonic" effect, a laser-induced acoustic artifact. Thus, for deaf individuals who use the auditory brainstem implant, INS alone did not appear promising as a new approach.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.