Evidence map›Paper›PMID 24508364›Full record

Trial reportJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2014

Right ventricular mechanics using a novel comprehensive three-view echocardiographic strain analysis in a normal population.

Daniel Forsha, Niels Risum, P Andrea Kropf, Sudarshan Rajagopal, P Brian Smith, Ronald J Kanter, Zainab Samad, Peter Sogaard, Piers Barker, Joseph Kisslo

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Observational
  10. Right Ventricular Longitudinal Strain Reproducibility Using Vendor-Dependent and Vendor-Independent Software.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2018
    Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Right ventricular function in preterm and term neonates: reference values for right ventricle areas and fractional area of change.Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography · 2015
    Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Daniel ForshaDivision of Pediatric Cardiology, Duke University Medical Center, Durham, North Carolina. Electronic address: daniel.forsha@duke.edu.
Niels RisumDepartment of Cardiology, Gentofte University Hospital, Gentofte, Denmark.
P Andrea KropfDivision of Pediatric Cardiology, Duke University Medical Center, Durham, North Carolina.
Sudarshan RajagopalDivision of Cardiovascular Disease, Duke University Medical Center, Durham, North Carolina.
P Brian SmithDuke Clinical Research Institute, Durham, North Carolina.
Ronald J KanterDivision of Pediatric Cardiology, Duke University Medical Center, Durham, North Carolina.
Zainab SamadDivision of Cardiovascular Disease, Duke University Medical Center, Durham, North Carolina.
Peter SogaardDepartment of Cardiology, Aalborg University, Aalborg, Denmark.
Piers BarkerDivision of Pediatric Cardiology, Duke University Medical Center, Durham, North Carolina.
Joseph KissloDivision of Cardiovascular Disease, Duke University Medical Center, Durham, North Carolina.

Funding

Duke CTSA (Composite)UL1TR001117 · NCATS · DUKE UNIVERSITY · PI BOULWARE, LEIGH E, LI, JENNIFER S · 2013 to 2017
$41.3M
NCATS NIH HHS UL1 TR001117NIAAA NIH HHS HHSN275201000003CNICHD NIH HHS HHSN267200700051CNICHD NIH HHS HHSN275201000003INIDDK NIH HHS HHSN267200700051C
6 · The paper itself

Abstract

backgroundAlthough quantitative right ventricular (RV) strain analysis may be useful in congenital and acquired heart disease populations with RV failure, a comprehensive, standardized approach is lacking. An 18-segment RV strain analysis obtained from three standardized RV apical echocardiographic images was used to determine the feasibility, normal values, and reproducibility of the method in normal adults.

methodsForty healthy, prospectively enrolled volunteers with no cardiac histories and normal QRS durations underwent echocardiography optimized for strain analysis including three RV apical views. Two-dimensional speckle-tracking longitudinal strain analysis was performed using EchoPAC software. Eleven retrospectively identified subjects with RV disease were included as a pilot population. All had been imaged using the same protocol including the three RV apical views.

resultsAll control subjects had normal anatomic morphology and function by echocardiography. Feasibility of the RV strain analysis was good (adequate tracking in 696 of 720 segments [97%]). RV global peak systolic strain was -23 ± 2%. Peak strain was highest in the RV free wall and lowest in the septum. Dyssynchrony indices demonstrated no dyssynchrony using left ventricular criteria. Reproducibility of most strain measures was acceptable. This methodology identified important disease not seen in the four-chamber apical view alone in the pilot population of 11 patients with RV disease. Strain patterns and values were different from those in the control population, indicating that differences do exist from normal.

conclusionsEighteen-segment RV strain analysis is feasible, with strain measures falling into discrete ranges in this normal population. Those with RV disease illustrate the potential utility of this approach. These data indicate that this model can be used for more detailed studies evaluating abnormal RV populations, in which its full potential can be assessed.

Indexed as

AlgorithmsAdolescentAdultEchocardiography, Three-DimensionalElasticity Imaging TechniquesElastic ModulusFeasibility StudiesFemaleHeart VentriclesHumansImage EnhancementImage Interpretation, Computer-AssistedMaleMiddle AgedReference ValuesReproducibility of ResultsEchocardiographyFunctionRightStrainVentricle

Identifiers

PMID24508364
PMCPMC4052609

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.