ArticleCurrent biology : CB2014
Epistatic and combinatorial effects of pigmentary gene mutations in the domestic pigeon.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
47 citing papers in PubMed, 103 citations in OpenAlex.
- Population Structure and Genetic Diversity of Tumbler Pigeon Based on Whole-Genome Resequencing.Animals : an open access journal from MDPI · 2026Article
- Widespread Variation in EDNRB2 Is Associated With Diverse Melanin Loss Phenotypes Across Avian Species.Molecular biology and evolution · 2025Article
- The Genetic Structure and Diversity of Different Pigeon Breeds Based on a 5 K Single Nucleotide Polymorphism Chip.Animals : an open access journal from MDPI · 2025Article
- Widespread variation inbioRxiv : the preprint server for biology · 2025Article
- Environmental and social correlates of the plumage color polymorphism in an urban dweller, feral pigeon (Columba livia f. domestica).Scientific reports · 2024Article
- Evolution of Chromosomal Inversions across an Avian Radiation.Molecular biology and evolution · 2024Article
- Mutations in SLC45A2 lead to loss of melanin in parrot feathers.G3 (Bethesda, Md.) · 2024Article
- Genomic data reveal unexpected relatedness between a brown female Eastern Bluebird and her brood.Ecology and evolution · 2024Article
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- The draft genome of the Temminck's tragopan (Tragopan temminckii) with evolutionary implications.BMC genomics · 2023Article
- An allelic series at the EDNRB2 locus controls diverse piebalding patterns in the domestic pigeon.PLoS genetics · 2023Article
- Association between Synonymous SNPs ofAnimals : an open access journal from MDPI · 2022Article
- A DNA Replication Mechanism Can Explain Structural Variation at the PigeonBiomolecules · 2022Article
- Draft genome assemblies of four manakins.Scientific data · 2022Article
- A high-quality assembly reveals genomic characteristics, phylogenetic status, and causal genes for leucism plumage of Indian peafowl.GigaScience · 2022Article
- Whole-genome sequencing reveals the artificial selection and local environmental adaptability of pigeons (Evolutionary applications · 2022Article
- A large and diverse autosomal haplotype is associated with sex-linked colour polymorphism in the guppy.Nature communications · 2022Article
- Article
- Two Genomic Loci Control Three Eye Colors in the Domestic Pigeon (Columba livia).Molecular biology and evolution · 2021Article
- A ROR2 coding variant is associated with craniofacial variation in domestic pigeons.Current biology : CB · 2021Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
Understanding the molecular basis of phenotypic diversity is a critical challenge in biology, yet we know little about the mechanistic effects of different mutations and epistatic relationships among loci that contribute to complex traits. Pigmentation genetics offers a powerful model for identifying mutations underlying diversity and for determining how additional complexity emerges from interactions among loci. Centuries of artificial selection in domestic rock pigeons (Columba livia) have cultivated tremendous variation in plumage pigmentation through the combined effects of dozens of loci. The dominance and epistatic hierarchies of key loci governing this diversity are known through classical genetic studies, but their molecular identities and the mechanisms of their genetic interactions remain unknown. Here we identify protein-coding and cis-regulatory mutations in Tyrp1, Sox10, and Slc45a2 that underlie classical color phenotypes of pigeons and present a mechanistic explanation of their dominance and epistatic relationships. We also find unanticipated allelic heterogeneity at Tyrp1 and Sox10, indicating that color variants evolved repeatedly though mutations in the same genes. These results demonstrate how a spectrum of coding and regulatory mutations in a small number of genes can interact to generate substantial phenotypic diversity in a classic Darwinian model of evolution.
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