ArticleCurrent biology : CB2014
Spontaneous activity governs olfactory representations in spatially organized habenular microcircuits.
Article in Current biology : CB, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Modulation of habenula axon terminals supports action-outcome associations in larval zebrafish.Nature communications · 2026Article
- Inferring brain-wide interactions using data-constrained recurrent neural network models.Neuron · 2026Article
- Topographically organized dorsal raphe activity modulates forebrain sensory-motor representations and contributes to defensive behaviors.Nature communications · 2026Article
- Trans-Synaptic Virus Tracing Reveals Reciprocal Connections of the Interpeduncular Nucleus With the Mood, Exteroceptive, Interoceptive, and Motor Control Systems.The Journal of comparative neurology · 2025Article
- Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors.Nature communications · 2025Article
- Evidence for Auditory Stimulus-Specific Adaptation But Not Deviance Detection in Larval Zebrafish Brains.The Journal of comparative neurology · 2025Article
- Ciliogenesis defects after neurulation impact brain development and neuronal activity in larval zebrafish.iScience · 2024Article
- EVIDENCE FOR AUDITORY STIMULUS-SPECIFIC ADAPTATION BUT NOT DEVIANCE DETECTION IN LARVAL ZEBRAFISH BRAINS.bioRxiv : the preprint server for biology · 2024Article
- Review
- The preoptic area and dorsal habenula jointly support homeostatic navigation in larval zebrafish.Current biology : CB · 2024Article
- The forkhead transcription factor Foxj1 controls vertebrate olfactory cilia biogenesis and sensory neuron differentiation.PLoS biology · 2024Article
- Pheromone Perception in Fish: Mechanisms and Modulation by Internal Status.Integrative and comparative biology · 2023Review
- Elevated photic response is followed by a rapid decay and depressed state in ictogenic networks.Epilepsia · 2022Article
- Habenula bibliometrics: Thematic development and research fronts of a resurgent field.Frontiers in integrative neuroscience · 2022Article
- Article
- Experience-dependent plasticity modulates ongoing activity in the antennal lobe and enhances odor representations.Cell reports · 2021Article
- Article
- Trans-inhibition of axon terminals underlies competition in the habenulo-interpeduncular pathway.Current biology : CB · 2021Article
- The habenula clock influences response to a stressor.Neurobiology of stress · 2021Article
- Ongoing habenular activity is driven by forebrain networks and modulated by olfactory stimuli.Current biology : CB · 2021Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
The medial habenula relays information from the sensory areas via the interpeduncular nucleus to the periaqueductal gray that regulates animal behavior under stress conditions. Ablation of the dorsal habenula (dHb) in zebrafish, which is equivalent to the mammalian medial habenula, was shown to perturb experience-dependent fear. Therefore, understanding dHb function is important for understanding the neural basis of fear. In zebrafish, the dHb receives inputs from the mitral cells (MCs) of the olfactory bulb (OB), and odors can trigger distinct behaviors (e.g., feeding, courtship, alarm). However, it is unclear how the dHb processes olfactory information and how these computations relate to behavior. In this study, we demonstrate that the odor responses in the dHb are asymmetric and spatially organized despite the unorganized OB inputs. Moreover, we show that the spontaneous dHb activity is not random but structured into functionally and spatially organized clusters of neurons, which reflects the favored states of the dHb network. These dHb clusters are also preserved during odor stimulation and govern olfactory responses. Finally, we show that functional dHb clusters overlap with genetically defined dHb neurons, which regulate experience-dependent fear. Thus, we propose that the dHb is composed of functionally, spatially, and genetically distinct microcircuits that regulate different behavioral programs.
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