Trial reportJournal of cardiac failure2014
The effect of vitamin d on aldosterone and health status in patients with heart failure.
Trial report in Journal of cardiac failure, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 5 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Vitamin D on Cardiac Function in Heart Failure: A Systematic Review and Meta-Analysis of 10 RCTs.Reviews in cardiovascular medicine · 2023Pooled it
- Vitamin D and adrenal gland: Myth or reality? A systematic review.Frontiers in endocrinology · 2022Pooled it
- Effect of vitamin D on ventricular remodelling in heart failure: a meta-analysis of randomised controlled trials.BMJ open · 2018Pooled it
- Effects of vitamin D supplementation on inflammatory markers in heart failure: a systematic review and meta-analysis of randomized controlled trials.Scientific reports · 2018Pooled it
- Vitamin D Supplementation in the Treatment of Chronic Heart Failure: A Meta-analysis of Randomized Controlled Trials.Clinical cardiology · 2016Pooled it
- Effects of Vitamin D on Cardiac Function in Patients With Chronic HF: The VINDICATE Study.Journal of the American College of Cardiology · 2016Trial
- Effect of vitamin D on renin concentration in chronic heart failure patients: a randomized placebo-controlled trial.Global cardiology science & practice · 2025Article
- Heart Failure and Osteoporosis: Shared Challenges in the Aging Population.Journal of cardiovascular development and disease · 2025Review
- Diastolic Dysfunction and Renal Disease: Analysis, Mechanisms, and Different Perspectives.Cureus · 2025Review
- Article
- Understanding the Role of Vitamin D in Heart Failure.Reviews in cardiovascular medicine · 2023Review
- Is Hypovitaminosis D a Risk Factor for Heart Failure?Life (Basel, Switzerland) · 2023Review
- Review
- Article
- Bone in heart failure.Journal of cachexia, sarcopenia and muscle · 2020Review
- Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure.European journal of nutrition · 2019Article
- Role of Vitamin D Beyond the Skeletal Function: A Review of the Molecular and Clinical Studies.International journal of molecular sciences · 2018Review
- Effects of Vitamin D Supplementation on Renin and Aldosterone Concentrations in Patients with Advanced Heart Failure: The EVITA Trial.International journal of endocrinology · 2018Article
- Dietary Supplements and Cardiovascular Diseases.International journal of preventive medicine · 2018Review
- Vitamin D and Heart Failure.Current heart failure reports · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundVitamin D deficiency is associated with heart failure (HF) events, and in animal models vitamin D down-regulates renin-angiotensin-aldosterone system hormones.
methodsPatients with New York Heart Association (NYHA) functional class II-IV HF and a 25OH-D level ≤37.5 ng/mL received 50,000 IU vitamin D3 weekly (n = 31) or placebo (n = 33) for 6 months. Serum aldosterone, renin, echocardiography, and health status were determined at baseline and 6 months.
resultsMean age of participants was 65.9 ± 10.4 years, 48% were women, 64% were African American, mean ejection fraction was 37.6 ± 13.9%, 36% were in NYHA functional class III, and 64% were in class II. The vitamin D group increased serum 25OH-D (19.1 ± 9.3 to 61.7 ± 20.3 ng/mL) and the placebo group did not (17.8 ± 9.0 to 17.4 ± 9.8 ng/mL). Aldosterone decreased in the vitamin D group (10.0 ± 11.9 to 6.2 ± 11.6 ng/dL) and not in the placebo group (8.9 ± 8.6 to 9.0 ± 12.4 ng/dL; P = .02). There was no difference between groups in renin, echocardiographic measures, or health status from baseline to 6 months. Modeling indicated that variables which predicted change in aldosterone included receiving vitamin D, increasing age, African American race, and lower glomerular filtration rate.
conclusionsVitamin D3 repletion decreases aldosterone in patients with HF and low serum vitamin D. Vitamin D may be an important adjunct to standard HF therapy. Further study will assess if vitamin D provides long-term benefit for patients with HF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.