Evidence map›Paper›PMID 24508003›Full record

ArticleDrug and alcohol dependence2014

Absence of neurocognitive impairment in a large Chinese sample of HCV-infected injection drug users receiving methadone treatment.

Saurabh Gupta, Jennifer E Iudicello, Chuan Shi, Scott Letendre, Adam Knight, Jianhua Li, Patricia K Riggs, Donald R Franklin, Nichole Duarte, Hua Jin and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug and alcohol dependence, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. HIV-Associated Neurocognitive Disorders: A Global Perspective.Journal of the International Neuropsychological Society : JINS · 2017
    Review
  8. Neuropsychological Assessment: Past and Future.Journal of the International Neuropsychological Society : JINS · 2017
    Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Saurabh GuptaHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA; Gupta Psychology & Assessment Services, USA.
Jennifer E IudicelloHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA.
Chuan ShiThe Institute of Mental Health at Peking University, Beijing, China.
Scott LetendreHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA.
Adam KnightHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA.
Jianhua LiChina Yunnan Institute of Drug Abuse, Kunming, China.
Patricia K RiggsHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA.
Donald R FranklinHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA.
Nichole DuarteHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA; Gupta Psychology & Assessment Services, USA.
Hua JinHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA; VA San Diego Healthcare System, San Diego, CA, USA.
J Hampton AtkinsonVA San Diego Healthcare System, San Diego, CA, USA; HIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA.
Xin YuThe Institute of Mental Health at Peking University, Beijing, China.
Zunyou WuChina Centers for Disease Control (China CDC), Beijing, China.
Igor GrantHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA.
Robert K HeatonHIV Neurobehavioral Research Program (HNRP), University of California San Diego, CA, USA. Electronic address: rheaton@ucsd.edu.
HNRC China Collaboration Group
University of California, San Diego · USNeurobehavioral Research (United States) · USPeking University Sixth Hospital · CNChinese Center For Disease Control and Prevention · CNVA San Diego Healthcare System · USYunnan Institute For Drug Abuse · CN

Funding

STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Training in Research on Addictions in Interdisciplinary NeuroAIDS (TRAIN)T32DA031098 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Jennifer E Iudicello, DAVID J MOORE · 2011 to 2026
$4.6M
Neurobehavioral Effects of HIV &Host Genetics in ChinaR01MH073433 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HEATON, ROBERT KERNACHAN · 2005 to 2009
$3.2M
Clinical Trial of CNS Penetrating ART to Prevent NeuroAIDS in ChinaR01MH092225 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2010 to 2014
$2.8M
Midcareer Investigator Award in Patient-Oriented NeuroAIDS ResearchK24MH097673 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LETENDRE, SCOTT L · 2013 to 2017
$917k
Biomarkers of Blood Brain Barrier Injury in Methamphetamine Use and HIV DiseaseK23DA037793 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI IUDICELLO, JENNIFER E · 2014 to 2018
$915k
NIDA NIH HHS K23 DA037793NIDA NIH HHS L30 DA034362NIDA NIH HHS L30DA034362NIDA NIH HHS T32 DA031098NIDA NIH HHS T32DA031098NIMH NIH HHS K24 MH097673NIMH NIH HHS P30 MH062512NIMH NIH HHS P30MH062512NIMH NIH HHS R01 MH073433NIMH NIH HHS R01MH073433NIMH NIH HHS R01 MH092225
6 · The paper itself

Abstract

backgroundPrior research has demonstrated neuropsychological (NP) impairment in persons with histories of injection drug use (IDU), hepatitis C virus (HCV) infection, and methadone maintenance treatment (MMT), individually, but little is known about the NP effects of these three risk factors in combination. This issue is particularly important in China, which is addressing its highly HCV-comorbid IDU epidemic with widespread government sponsored MMT, especially in light of recent evidence suggesting that methadone may be neuroprotective in some circumstances.

methodsWe administered a comprehensive NP test battery to 195 Chinese heroin IDU individuals taking MMT (IDU+ group), the majority of whom were also HCV+ (87%; n=169), and compared their NP performance to that of 198 demographically comparable, non-IDU Chinese controls (IDU- group). All participants in both groups tested negative for HIV infection, which is also a common comorbidity in the Chinese IDU population.

resultsThe IDU+ group did not have an increased rate of global NP impairment, or perform significantly worse on any individual NP test measure. Within the IDU+ group, liver disease characteristics and reported details of heroin use were not significantly associated with NP performance.

conclusionFailure to detect NP impairment in IDU+ subjects with or without HCV infection was surprising, particularly considering the previously demonstrated sensitivity of our NP battery to neurocognitive disorders associated with HIV infection in China. One possible explanation, which should be explored in future research, is the potential neuroprotective effect of methadone in the context of HCV infection and/or heroin withdrawal.

Indexed as

Asian PeopleNeuropsychological TestsOpiate Substitution TreatmentAdultCognition DisordersFemaleHepatitis CHumansMaleMethadoneRetrospective StudiesRisk FactorsSubstance Abuse, IntravenousTreatment OutcomeMethadoneChinaHCVInjection drugsNeurocognitive impairment

Identifiers

PMID24508003
PMCPMC3961522
OpenAlexW1996377411

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.