Evidence map›Paper›PMID 24507939›Full record

ReviewCytokine & growth factor reviews2014

New roles for the BLyS/BAFF family in antigen-experienced B cell niches.

Radhika Goenka, Jean L Scholz, Vishal J Sindhava, Michael P Cancro

Abstract readReview
In one paragraph

Review in Cytokine & growth factor reviews, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

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  13. Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients.Journal of the American Society of Nephrology : JASN · 2017
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Radhika GoenkaAbbVie Bioresearch Center, 100 Research Drive, Worcester, MA 01605, United States. Electronic address: radhika.goenka@abbvie.com.
Jean L ScholzDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, United States. Electronic address: jeanl@mail.med.upenn.edu.
Vishal J SindhavaDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, United States. Electronic address: sindhava@mail.med.upenn.edu.
Michael P CancroDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6082, United States. Electronic address: cancro@mail.med.upenn.edu.
University of Pennsylvania · USAbbVie (United States) · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ROBERT GROSS · 1999 to 2026
$78.6M
Immune System Development and RegulationT32AI055428 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ALLMAN, DAVID M, OLIVER, PAULA MARIA · 2003 to 2025
$4.2M
Transitional B cell selection during peripheral B lymphopenia and reconstitutionR01AI073939 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CANCRO, MICHAEL PAUL · 2007 to 2011
$2.1M
ROLE OF BLYS IN PERIPHERAL B CELL SELECTION AND SURVIVALR01AI054488 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI CANCRO, MICHAEL PAUL · 2004 to 2008
$1.9M
NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI054488NIAID NIH HHS R01 AI073939NIAID NIH HHS T32 AI055428
6 · The paper itself

Abstract

BLyS family members govern selection and survival of cells in the pre-immune B cell compartment, and emerging evidence suggests similar roles in antigen-experienced B cell pools. We review the features of this family, with particular emphasis on recent findings of how BLyS influences affinity maturation in germinal centers, which lie at the intersection of the pre-immune and antigen-experienced B cell compartments. We propose a model whereby tolerogenic selection at the transitional stage and affinity maturation in the germinal center employ the same BLyS driven mechanism.

Indexed as

Antigen PresentationB-Cell Activating FactorB-LymphocytesCell DifferentiationCell SurvivalGerminal CenterHumansTumor Necrosis Factor Ligand Superfamily Member 13B-Cell Activating FactorTNFSF13B protein, humanTumor Necrosis Factor Ligand Superfamily Member 13BAFFBLySGerminal centerTACI

Identifiers

PMID24507939
PMCPMC3999179
OpenAlexW2083800863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.