Evidence map›Paper›PMID 24507775›Full record

ArticleAmerican journal of human genetics2014

Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol.

Leslie A Lange, Youna Hu, He Zhang, Chenyi Xue, Ellen M Schmidt, Zheng-Zheng Tang, Chris Bizon, Ethan M Lange, Joshua D Smith, Emily H Turner and 93 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 4 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 4 syntheses or guidelines pooled it, 215 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Unravelling the genetic architecture of cerebral small vessel disease in the context of stroke.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Review
  7. Article
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  15. Article
  16. Role of non-coding variants in cardiovascular disease.Journal of cellular and molecular medicine · 2023
    Review
  17. Review
  18. Article
  19. Article
  20. Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

103 authors at 20 institutions in 9 countries.

Leslie A LangeDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Youna HuDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
He ZhangDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Chenyi XueDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Ellen M SchmidtDepartment of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA.
Zheng-Zheng TangDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Chris BizonRenaissance Computing Institute, Chapel Hill, NC 27517, USA.
Ethan M LangeDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Joshua D SmithDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Emily H TurnerDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Goo JunDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Hyun Min KangDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Gina PelosoCenter for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA.
Paul AuerDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; School of Public Health, University of Wisconsin - Milwaukee, Milwaukee, WI 53201, USA.
Kuo-Ping LiDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Jason FlannickBroad Institute of Harvard and MIT, Cambridge, MA 02141, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.
Ji ZhangDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Christian FuchsbergerDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Kyle GaultonWellcome Trust Centre for Human Genetics, University of Oxford, OX1 2JD Oxford, UK.
Cecilia LindgrenWellcome Trust Centre for Human Genetics, University of Oxford, OX1 2JD Oxford, UK.
Adam LockeDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Alisa ManningProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA; School of Public Health, University of Wisconsin - Milwaukee, Milwaukee, WI 53201, USA; Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA; Department of Genetics, Harvard Medical School, Boston, MA 02138, USA.
Xueling SimDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Manuel A RivasWellcome Trust Centre for Human Genetics, University of Oxford, OX1 2JD Oxford, UK.
Oddgeir L HolmenHUNT Research Center, Department of Public Health, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Omri GottesmanThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Yingchang LuThe Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Douglas RuderferDivision of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Eli A StahlDivision of Psychiatric Genomics, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Qing DuanDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Yun LiDepartment of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Department of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Peter DurdaDepartment of Pathology, University of Vermont, Colchester, VT 05446, USA.
Shuo JiaoDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Aaron IsaacsGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015 DR Rotterdam, the Netherlands.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, 3000 DR Rotterdam, the Netherlands.
Joshua C BisCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Adolfo CorreaDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Michael E GriswoldDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Johanna JakobsdottirIcelandic Heart Association, IS-201 Kopavogur, Iceland.
Albert V SmithIcelandic Heart Association, IS-201 Kopavogur, Iceland; University of Iceland, 101 Reykjavik, Iceland.
Pamela J SchreinerDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Qunyuan ZhangDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Jennifer E HuffmanMedical Research Center for Human Genetics, Medical Research Center Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, UK.
Jacy CrosbyHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Christina L WasselDepartment of Epidemiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Ron DoCenter for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Lisa W MartinDivision of Cardiology, George Washington School of Medicine and Health Sciences, Washington, DC 20037, USA.
Jennifer G RobinsonDepartments of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, USA.
Themistocles L AssimesDepartment of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
David R CrosslinDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Biostatistics, University of Washington, Seattle, WA 98195, USA.
Elisabeth A RosenthalDivision of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
Michael TsaiDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.
Mark J RiederDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Deborah N FarlowBroad Institute of Harvard and MIT, Cambridge, MA 02141, USA.
Aaron R FolsomDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN 55454, USA.
Thomas LumleyDepartment of Biostatistics, University of Washington, Seattle, WA 98195, USA; Department of Statistics, University of Auckland, Auckland 1142, New Zealand.
Ervin R FoxDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Christopher S CarlsonDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Ulrike PetersDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Rebecca D JacksonDivision of Endocrinology, Ohio State University, Columbus, OH 43210, USA.
Cornelia M van DuijnGenetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, 3015 DR Rotterdam, the Netherlands.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, 3000 DR Rotterdam, the Netherlands.
Daniel LevyCenter for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA.
Jerome I RotterInstitute for Translational Genomics and Population Sciences, Los Angeles BioMedical Research Institute, and Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Herman A TaylorDepartment of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA; Tougaloo College, Jackson, MS 39174, USA; Jackson State University, Jackson, MS 39217, USA.
Vilmundur GudnasonIcelandic Heart Association, IS-201 Kopavogur, Iceland; University of Iceland, 101 Reykjavik, Iceland.
David S SiscovickCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington Medical Center, Seattle, WA 98195, USA.
Myriam FornageHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA; Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Ingrid B BoreckiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Caroline HaywardMedical Research Center for Human Genetics, Medical Research Center Institute of Genetics and Molecular Medicine, University of Edinburgh, EH4 2XU Edinburgh, UK.
Igor RudanCentre for Population Health Sciences, Medical School, University of Edinburgh, EH8 9YL Edinburgh, UK.
Y Eugene ChenDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA.
Erwin P BottingerThe Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Ruth J F LoosThe Genetics of Obesity and Related Metabolic Traits Program, The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Pål SætromDepartment of Computer and Information Science, Norwegian University of Science and Technology, 7491 Trondheim, Norway; Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway.
Kristian HveemHUNT Research Center, Department of Public Health, Norwegian University of Science and Technology, 7600 Levanger, Norway.
Michael BoehnkeDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Leif GroopDepartment of Clinical Sciences, Diabetes, and Endocrinology, Lund University, Skåne University Hospital, 221 00 Malmö, Sweden; Glostrup Research Institute, Glostrup University Hospital, 2600 Glostrup, Denmark.
Mark McCarthyOxford Centre for Diabetes, Endocrinology, and Metabolism and Oxford National Institute for Health Research Biomedical Research Centre, University of Oxford, Churchill Hospital, OX1 2JD Oxford, UK.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Neuherberg, Germany; Institute of Human Genetics, Technical University of Munich, 85764 Neuherberg, Germany.
Christie M BallantyneBaylor College of Medicine, Houston, TX 77030, USA; Houston Methodist DeBakey Heart and Vascular Center, Houston, TX 77030, USA.
Stacey B GabrielProgram in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA.
Christopher J O'DonnellCenter for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
Wendy S PostDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Kari E NorthDepartment of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Alexander P ReinerDepartment of Epidemiology, University of Washington, Seattle, WA 98195, USA.
Eric BoerwinkleHuman Genetics Center, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA 98195, USA; Department of Epidemiology, University of Washington, Seattle, WA 98195, USA; Department of Medicine, University of Washington Medical Center, Seattle, WA 98195, USA; Group Health Research Institute, Group Health Cooperative, Seattle, WA 98195, USA.
David AltshulerCenter for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02138, USA.
Sekar KathiresanCenter for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA 02141, USA; Cardiology Division, Massachusetts General Hospital, Boston, MA 02114, USA.
Dan-Yu LinDepartment of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Gail P JarvikDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA; Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA 98195, USA.
L Adrienne CupplesCenter for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA 01702, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA 02215, USA.
Charles KooperbergDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
James G WilsonDepartment of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Deborah A NickersonDepartment of Genome Sciences, University of Washington, Seattle, WA 98195, USA.
Goncalo R AbecasisDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Stephen S RichCenter for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA.
Russell P TracyDepartment of Pathology, University of Vermont, Colchester, VT 05446, USA; Department of Biochemistry, University of Vermont, Burlington, VT 05405, USA.
Cristen J WillerDivision of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA; Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: cristen@umich.edu.
NHLBI Grand Opportunity Exome Sequencing Project
University of Michigan · USUniversity of North Carolina at Chapel Hill · USUniversity of Washington · USBroad Institute · USFred Hutch Cancer Center · USUniversity of Minnesota · USUniversity of Mississippi Medical Center · USUniversity of Vermont · USCentre for Human Genetics · GBIcahn School of Medicine at Mount Sinai · USNational Heart Lung and Blood Institute · USTougaloo College · USUniversity of Iowa · USChurchill Hospital · GBErasmus MC · NLGeorge Washington University · USHelmholtz Zentrum München · DEJackson Memorial Hospital · USThe University of Texas Health Science Center at Houston · USUniversity of Iceland · IS

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Comprehensive Sequencing and Analysis of Variation in NHLBI CohortsUC2HL102925 · NHLBI · BROAD INSTITUTE, INC. · PI ALTSHULER, DAVID, GABRIEL, STACEY · 2010 to 2010
$14.7M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
Identifying Genes for Type 2 Diabetes: FUSIONU01DK062370 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOEHNKE, MICHAEL L, SCOTT, LAURA J. · 2009 to 2021
$11.6M
Northwest Genomics CenterRC2HL102926 · NHLBI · UNIVERSITY OF WASHINGTON · PI GREEN, PHILIP P, NICKERSON, DEBORAH A · 2009 to 2009
$11.0M
Comprehensive Sequencing and Analysis of Variation in NHLBI CohortsRC2HL102925 · NHLBI · BROAD INSTITUTE, INC. · PI ALTSHULER, DAVID, GABRIEL, STACEY · 2009 to 2009
$10.2M
JHU-UMD Diabetes Research CenterP30DK079637 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI WONDISFORD, FREDRIC E. · 2013 to 2017
$9.7M
Using genetics to discover mechanisms of myocardial infarctionR01HL109946 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI YUQING Eugene CHEN, Ida Liisa Surakka · 2011 to 2026
$8.9M
Understanding Obesity In Relation to the Built EnvironmentP20MD006899 · NIMHD · JACKSON STATE UNIVERSITY · PI ANTOINE-LAVIGNE, DONNA A · 2012 to 2016
$5.3M
Medical Research Council MC_PC_U127561128NCATS NIH HHS UL1 TR000124NCI NIH HHS R01 CA082659NHGRI NIH HHS U01 HG007416NHLBI NIH HHS R00 HL094535NHLBI NIH HHS R00HL94535NHLBI NIH HHS R01 HL067406NHLBI NIH HHS R01 HL107816NHLBI NIH HHS R01HL107816NHLBI NIH HHS R01 HL109946NHLBI NIH HHS R01 HL67406NHLBI NIH HHS RC2 HL-102923NHLBI NIH HHS RC2 HL102923NHLBI NIH HHS RC2 HL-102924NHLBI NIH HHS RC2 HL102924NHLBI NIH HHS RC2 HL-102925NHLBI NIH HHS RC2 HL102925NHLBI NIH HHS RC2 HL-102926NHLBI NIH HHS RC2 HL102926NHLBI NIH HHS RC2 HL-103010NHLBI NIH HHS RC2 HL103010NHLBI NIH HHS T32 HL007208NHLBI NIH HHS UC2 HL102924NHLBI NIH HHS UC2 HL102925NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG033193NIA NIH HHS U01 AG049505NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK079637NIDDK NIH HHS U01 DK062370NIMHD NIH HHS P20 MD006899Wellcome Trust 090532
6 · The paper itself

Abstract

Elevated low-density lipoprotein cholesterol (LDL-C) is a treatable, heritable risk factor for cardiovascular disease. Genome-wide association studies (GWASs) have identified 157 variants associated with lipid levels but are not well suited to assess the impact of rare and low-frequency variants. To determine whether rare or low-frequency coding variants are associated with LDL-C, we exome sequenced 2,005 individuals, including 554 individuals selected for extreme LDL-C (>98(th) or <2(nd) percentile). Follow-up analyses included sequencing of 1,302 additional individuals and genotype-based analysis of 52,221 individuals. We observed significant evidence of association between LDL-C and the burden of rare or low-frequency variants in PNPLA5, encoding a phospholipase-domain-containing protein, and both known and previously unidentified variants in PCSK9, LDLR and APOB, three known lipid-related genes. The effect sizes for the burden of rare variants for each associated gene were substantially higher than those observed for individual SNPs identified from GWASs. We replicated the PNPLA5 signal in an independent large-scale sequencing study of 2,084 individuals. In conclusion, this large whole-exome-sequencing study for LDL-C identified a gene not known to be implicated in LDL-C and provides unique insight into the design and analysis of similar experiments.

Indexed as

ExomeGene FrequencyGenome-Wide Association StudyPolymorphism, Single NucleotideAcyltransferasesAdultAgedApolipoproteins ECholesterol, LDLCohort StudiesDyslipidemiasFemaleFollow-Up StudiesGenetic CodeGenotypeHumansAcyltransferasesApolipoproteins ECholesterol, LDLLDLR protein, humanLipasePCSK9 protein, humanPNPLA5 protein, humanProprotein Convertase 9Proprotein ConvertasesReceptors, LDLSerine Endopeptidases

Identifiers

PMID24507775
PMCPMC3928660
OpenAlexW2113547573

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.